Now showing items 4886-4905 of 12797

    • Functional Analysis of Vertebrate Msl2 

      Lai, Zheng (2014-02-12)
      hMSL2 (Male Specific Lethal 2, human) is a RING finger protein with E3 ubiquitin ligase activity. Although it has been shown to target histone H2B at lysine 34 and p53 at lysine 351, suggesting roles in transcription ...
    • A functional approach to characterising the microbial communities underpinning low temperature anaerobic digestion 

      Gunnigle, Eoin (2013-03-06)
      Low-temperature anaerobic digestion (LTAD) presents a sustainable, cost-efficient technology for the treatment of a vast array of wastewater streams. However, this microbially-mediated process requires further understanding ...
    • Functional characterization of orphan genes in Arabidopsis thaliana 

      Swamidatta, Sandesh (2015-01-28)
      All organisms are known to contain a unique set of genes called 'orphan genes', which do not share any similarity with genes or protein domains in other evolutionary lineages. Such orphan genes can impart unique traits to ...
    • Functional coupling of beta(3)-adrenoceptors and large conductance calcium-activated potassium channels in human uterine myocytes 

      Doheny, Helen C.; Lynch, Caoimhe M.; Smith, Terry; Morrison, John J. (Endocrine Society, 2005-07-02)
      Context: beta(3)-Adrenoreceptor modulation in human myometrium during pregnancy is linked functionally to myometrial inhibition. Maxi-K+ channels (BKCa) play a significant role in modulating cell membrane potential and ...
    • Functional coupling of β3-adrenoceptors and large conductance calcium-activated potassium channels in human uterine myocytes 

      Doheny, Helen C.; Lynch, Caoimhe M.; Smith, Terry J.; Morrison, John J. (The Endocrine Society, 2005-10-01)
      Context: beta(3)-Adrenoreceptor modulation in human myometrium during pregnancy is linked functionally to myometrial inhibition. Maxi-K(+) channels (BK(Ca)) play a significant role in modulating cell membrane potential and ...
    • Functional dissection of the Smc5/6 complex: roles of the SUMO ligase Nse2/Mms21 in the maintenance of genome stability 

      Kliszczak, Maciej (2011-06)
      Nse2/ Mms21 is an E3 SUMO ligase component of the Smc5/6 complex, which plays multiple roles in maintaining genome stability. To study the functions of the vertebrate Nse2 orthologue, we generated Nse2-deficient chicken ...
    • Functional expression of fasciola hepatica cathepsin l1 in saccharomyces cerevisiae 

      Roche, Leda; Dowd, Andrew J.; Tort, Jose; McGonigle, Sharon; McSweeney, Aengus; Curley, G. Paul; Ryan, Thecla; Dalton, John P. (Wiley-Blackwell, 1997-04-15)
      A cDNA encoding the complete precursor of a Fasciola hepatica cathepsin L protease was isolated and sequenced. Functionally active enzyme was expressed and secreted by Saccharomyces cerevisiae transformed with a plasmid ...
    • Functional genomics of microrna- directed regulation of tumorigenesis in human cancer cells 

      Selcuklu, Duygu (2011-09-30)
      In the past few decades, microRNAs emerged as key regulators of gene expression in many fundamental biological processes such as development and differentiation as well as diseases. There are thousands of microRNAs that ...
    • Functional genomics of stress responses in fish 

      Prunet, Patrick; Cairns, Michael T.; Winberg, Svante; Pottinger, Thomas G. (Informa UK Limited, 2008-09-15)
      Our understanding of the mechanisms underlying stress responses in fish remains fragmentary. However new insights into these mechanisms and their biological significance have been provided by investigation at the transcriptional ...
    • Functional imaging for regenerative medicine 

      Leahy, Martin; Thompson, Kerry; Zafar, Haroon; Alexandrov, Sergey; Foley, Mark; O’Flatharta, Cathal; Dockery, Peter (Springer Nature, 2016-04-19)
      In vivo imaging is a platform technology with the power to put function in its natural structural context. With the drive to translate stem cell therapies into pre-clinical and clinical trials, early selection of the right ...
    • Functional responses and adaptation of mesophilic microbial communities to psychrophilic anaerobic digestion 

      Gunnigle, Eoin; Nielsen, Jeppe L.; Fuszard, Matthew; Botting, Catherine H.; Sheahan, Jerome; O'Flaherty, Vincent; Abram, Florence (Oxford University Press, 2015-10-27)
      Psychrophilic (<20°C) anaerobic digestion (AD) represents an attractive alternative to mesophilic wastewater treatment. In order to investigate the AD microbiome response to temperature change, with particular emphasis on ...
    • Functional responses and adaptation of mesophilic microbial communities to psychrophilic anaerobic digestion 

      Gunnigle, Eoin; Nielsen, Jeppe L.; Fuszard, Matthew; Botting, Catherine H.; Sheahan, Jerome; Vincent, O’Flaherty; Abram, Florence (Oxford University Press (OUP), 2015-10-26)
      Psychrophilic (&amp;lt; 20 degrees C) anaerobic digestion (AD) represents an attractive alternative to mesophilic wastewater treatment. In order to investigate the AD microbiome response to temperature change, with particular ...
    • Functional role of CCAN histone fold proteins in mitosis 

      Kaczmarczyk, Agnieszka (2012-05-31)
      Centromeres are chromosomal loci that direct segregation of the genome by specifying kinetochore assembly in mitosis and meiosis. Kinetochores are built upon centromeric chromatin, which contains the histone H3 variant ...
    • Functional safety of health information technology 

      Chadwick, Liam; Fallon, Enda F.; van der Putten, Wil J.; Kirrane, Frank (SAGE Publications, 2012-03-01)
      In an effort to improve patient safety and reduce adverse events, there has been a rapid growth in the utilisation of health information technology (HIT). However, little work has examined the safety of the HIT systems ...
    • Functional screening of human faecal microbiome metagenome library for glycoside hydrolase enzymes 

      Mulualem, Daniel (NUI Galway, 2020-04-24)
      Members of the human gut microbiota use glycoside hydrolase (GH) enzymes, such as sialidases, α-fucosidases and β-galactosidases to forage on host mucin glycans and dietary fibers. A human faecal metagenomic library was ...
    • Functional studies on the role of notch signaling in hydractinia development 

      Gahan, James M.; Schnitzler, Christine E.; DuBuc, Timothy Q.; Doonan, Liam B.; Kanska, Justyna; Gornik, Sebastian G.; Barreira, Sofia; Thompson, Kerry; Schiffer, Philipp; Baxevanis, Andreas D.; Frank, Uri (Elsevier BV, 2017-08-01)
      The function of Notch signaling was previously studied in two cnidarians, Hydra and Nematostella, representing the lineages Hydrozoa and Anthozoa, respectively. Using pharmacological inhibition in Hydra and a combination ...
    • Functional variants at the 11q13 risk locus for breast cancer regulate cyclin d1 expression through long-range enhancers 

      French, Juliet D.; Ghoussaini, Maya; Edwards, Stacey L.; Meyer, Kerstin B.; Michailidou, Kyriaki; Ahmed, Shahana; Khan, Sofia; Maranian, Mel J.; O’Reilly, Martin; Hillman, Kristine M.; Betts, Joshua A.; Carroll, Thomas; Bailey, Peter J.; Dicks, Ed; Beesley, Jonathan; Tyrer, Jonathan; Maia, Ana-Teresa; Beck, Andrew; Knoblauch, Nicholas W.; Chen, Constance; Kraft, Peter; Barnes, Daniel; González-Neira, Anna; Alonso, M. Rosario; Herrero, Daniel; Tessier, Daniel C.; Vincent, Daniel; Bacot, Francois; Luccarini, Craig; Baynes, Caroline; Conroy, Don; Dennis, Joe; Bolla, Manjeet K.; Wang, Qin; Hopper, John L.; Southey, Melissa C.; Schmidt, Marjanka K.; Broeks, Annegien; Verhoef, Senno; Cornelissen, Sten; Muir, Kenneth; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Fasching, Peter A.; Loehberg, Christian R.; Ekici, Arif B.; Beckmann, Matthias W.; Peto, Julian; dos Santos Silva, Isabel; Johnson, Nichola; Aitken, Zoe; Sawyer, Elinor J.; Tomlinson, Ian; Kerin, Michael J.; Miller, Nicola; Marme, Frederik; Schneeweiss, Andreas; Sohn, Christof; Burwinkel, Barbara; Guénel, Pascal; Truong, Thérèse; Laurent-Puig, Pierre; Menegaux, Florence; Bojesen, Stig E.; Nordestgaard, Børge G.; Nielsen, Sune F.; Flyger, Henrik; Milne, Roger L.; Zamora, M. Pilar; Arias Perez, Jose Ignacio; Benitez, Javier; Anton-Culver, Hoda; Brenner, Hermann; Müller, Heiko; Arndt, Volker; Stegmaier, Christa; Meindl, Alfons; Lichtner, Peter; Schmutzler, Rita K.; Engel, Christoph; Brauch, Hiltrud; Hamann, Ute; Justenhoven, Christina; Aaltonen, Kirsimari; Heikkilä, Päivi; Aittomäki, Kristiina; Blomqvist, Carl; Matsuo, Keitaro; Ito, Hidemi; Iwata, Hiroji; Sueta, Aiko; Bogdanova, Natalia V.; Antonenkova, Natalia N.; Dörk, Thilo; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M.; Wu, Anna H.; Tseng, Chiu-chen; Van Den Berg, David; Stram, Daniel O.; Lambrechts, Diether; Peeters, Stephanie; Smeets, Ann; Floris, Giuseppe; Chang-Claude, Jenny; Rudolph, Anja; Nickels, Stefan; Flesch-Janys, Dieter; Radice, Paolo; Peterlongo, Paolo; Bonanni, Bernardo; Sardella, Domenico; Couch, Fergus J.; Wang, Xianshu; Pankratz, Vernon S.; Lee, Adam; Giles, Graham G.; Severi, Gianluca; Baglietto, Laura; Haiman, Christopher A.; Henderson, Brian E.; Schumacher, Fredrick; Le Marchand, Loic; Simard, Jacques; Goldberg, Mark S.; Labrèche, France; Dumont, Martine; Teo, Soo Hwang; Yip, Cheng Har; Ng, Char-Hong; Vithana, Eranga Nishanthie; Kristensen, Vessela; Zheng, Wei; Deming-Halverson, Sandra; Shrubsole, Martha; Long, Jirong; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Andrulis, Irene L.; Knight, Julia A.; Glendon, Gord; Mulligan, Anna Marie; Devilee, Peter; Seynaeve, Caroline; García-Closas, Montserrat; Figueroa, Jonine; Chanock, Stephen J.; Lissowska, Jolanta; Czene, Kamila; Klevebring, Daniel; Schoof, Nils; Hooning, Maartje J.; Martens, John W.M.; Collée, J. Margriet; Tilanus-Linthorst, Madeleine; Hall, Per; Li, Jingmei; Liu, Jianjun; Humphreys, Keith; Shu, Xiao-Ou; Lu, Wei; Gao, Yu-Tang; Cai, Hui; Cox, Angela; Balasubramanian, Sabapathy P.; Blot, William; Signorello, Lisa B.; Cai, Qiuyin; Pharoah, Paul D.P.; Healey, Catherine S.; Shah, Mitul; Pooley, Karen A.; Kang, Daehee; Yoo, Keun-Young; Noh, Dong-Young; Hartman, Mikael; Miao, Hui; Sng, Jen-Hwei; Sim, Xueling; Jakubowska, Anna; Lubinski, Jan; Jaworska-Bieniek, Katarzyna; Durda, Katarzyna; Sangrajrang, Suleeporn; Gaborieau, Valerie; McKay, James; Toland, Amanda E.; Ambrosone, Christine B.; Yannoukakos, Drakoulis; Godwin, Andrew K.; Shen, Chen-Yang; Hsiung, Chia-Ni; Wu, Pei-Ei; Chen, Shou-Tung; Swerdlow, Anthony; Ashworth, Alan; Orr, Nick; Schoemaker, Minouk J.; Ponder, Bruce A.J.; Nevanlinna, Heli; Brown, Melissa A.; Chenevix-Trench, Georgia; Easton, Douglas F.; Dunning, Alison M. (Elsevier BV, 2013-04-01)
      Analysis of 4,405 variants in 89,050 European subjects from 41 case-control studies identified three independent association signals for estrogen-receptor-positive tumors at 11q13. The strongest signal maps to a transcriptional ...
    • Functional  -aminobutyrate shunt in listeria monocytogenes: role in acid tolerance and succinate biosynthesis 

      Feehily, C.; O'Byrne, C. P.; Karatzas, K. A. G. (American Society for Microbiology, 2012-10-12)
      Listeria monocytogenes, the causative agent of human listeriosis, is known for its ability to withstand severe environmental stresses. The glutamate decarboxylase (GAD) system is one of the principal systems utilized by ...
    • Functionality of ngf-protected pc12 cells following exposure to 6-hydroxydopamine 

      Kavanagh, Edel T.; Loughlin, John P.; Herbert, Kate Reed; Dockery, Peter; Samali, Afshin; Doyle, Karen M.; Gorman, Adrienne M. (Elsevier BV, 2006-12-01)
    • Functionalization and fragmentation during ambient organic aerosol aging: application of the 2-d volatility basis set to field studies 

      Murphy, B. N.; Donahue, N. M.; Fountoukis, C.; Dall'Osto, M.; O'Dowd, C.; Kiendler-Scharr, A.; Pandis, S. N. (Copernicus GmbH, 2012-11-16)
      Multigenerational oxidation chemistry of atmospheric organic compounds and its effects on aerosol loadings and chemical composition is investigated by implementing the Two-Dimensional Volatility Basis Set (2-D-VBS) in a ...