Now showing items 1-2 of 2

    • Differential activation of jnk1 isoforms by trail receptors modulate apoptosis of colon cancer cell lines 

      Mahalingam, D; Keane, M; Pirianov, G; Mehmet, H; Samali, A; Szegezdi, E (Springer Nature, 2009-04-07)
      Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis on binding to its receptors, death receptor 4 and 5 (DR4, DR5). TRAIL can also activate c-Jun N-terminal kinase (JNK) through the adaptor ...
    • Stem cells are resistant to trail receptor-mediated apoptosis 

      Szegezdi, Eva; O’Reilly, Aoife; Davy, Yeung; Vawda, Reaz; Taylor, Deanna L.; Murphy, Mary; Samali, Afshin; Mehmet, Huseyin (Wiley-Blackwell, 2009-11-01)
      New therapeutic approaches aim to eradicate tumours by expression of tumouricidal proteins in the tumour stroma. One such anti-neoplastic protein is tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) because ...