Now showing items 1-8 of 8

    • Differential activation of jnk1 isoforms by trail receptors modulate apoptosis of colon cancer cell lines 

      Mahalingam, D; Keane, M; Pirianov, G; Mehmet, H; Samali, A; Szegezdi, E (Springer Nature, 2009-04-07)
      Tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) induces apoptosis on binding to its receptors, death receptor 4 and 5 (DR4, DR5). TRAIL can also activate c-Jun N-terminal kinase (JNK) through the adaptor ...
    • Dr4-selective tumor necrosis factor-related apoptosis-inducing ligand (trail) variants obtained by structure-based design 

      Tur, Vicente; van der Sloot, Almer M.; Reis, Carlos R.; Szegezdi, Eva; Cool, Robbert H.; Samali, Afshin; Serrano, Luis; Quax, Wim J. (American Society for Biochemistry & Molecular Biology (ASBMB), 2008-05-12)
      Tumor necrosis factor-related apoptosis-inducing ligand ( TRAIL) is a potential anticancer agent that selectively induces apoptosis in a variety of cancer cells by interacting with death receptors DR4 and DR5. TRAIL can ...
    • Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing trail variants 

      Reis, C R; van der Sloot, A M; Natoni, A; Szegezdi, E; Setroikromo, R; Meijer, M; Sjollema, K; Stricher, F; Cool, R H; Samali, A; Serrano, L; Quax, W J (Springer Nature, 2010-10-01)
      The tumour necrosis factor family member TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in a variety of cancer cells through the activation of death receptors 4 (DR4) and 5 (DR5) and is considered ...
    • Stem cells are resistant to trail receptor-mediated apoptosis 

      Szegezdi, Eva; O’Reilly, Aoife; Davy, Yeung; Vawda, Reaz; Taylor, Deanna L.; Murphy, Mary; Samali, Afshin; Mehmet, Huseyin (Wiley-Blackwell, 2009-11-01)
      New therapeutic approaches aim to eradicate tumours by expression of tumouricidal proteins in the tumour stroma. One such anti-neoplastic protein is tumour necrosis factor-related apoptosis-inducing ligand (TRAIL) because ...
    • Synthetic constrained peptide selectively binds and antagonizes death receptor 5 

      Vrielink, Johanna; Heins, Mariette S.; Setroikromo, Rita; Szegezdi, Eva; Mullally, Margaret M.; Samali, Afshin; Quax, Wim J. (Wiley-Blackwell, 2010-02-12)
      Apoptosis or programmed cell death is an inherent part of the development and homeostasis of multicellular organisms. Dysregulation of apoptosis is implicated in the pathogenesis of diseases such as cancer, neurodegenerative ...
    • Targeting aml through dr4 with a novel variant of rhtrail 

      Szegezdi, Eva; Reis, Carlos R.; Sloot, Almer M. van der; Natoni, Alessandro; O’Reilly, Aoife; Reeve, Janice; Cool, Robbert H.; O’Dwyer, Michael; Knapper, Steven; Serrano, Luis; Quax, Wim J.; Samali, Afshin (Wiley-Blackwell, 2011-09-26)
      Despite progress in the treatment of acute myelogenous leukaemia (AML) the outcome often remains poor. Tumour necrosis factor related apoptosis-inducing ligand (TRAIL) is a promising therapeutic agent in many different ...
    • Trail receptor gene editing unveils trail-r1 as a master player of apoptosis induced by trail and er stres 

      Florent, Dufour; Thibault, Rattier; Andrei Alexandru, Constantinescu; Luciana, Zischler; Aymeric, Morlé; Hazem, Ben Mabrouk; Etienne, Humblin; Guillaume, Jacquemin; Eva, Szegezdi; Fabien, Delacote; Naziha, Marrakchi; Gilles, Guichard; Catherine, Pellat-Deceunyn; Pierre, Vacher; Patrick, Legembre; Carmen, Garrido; Micheau, Olivier (Impact Journals, LLC, 2016-12-27)
      TRAIL induces selective tumor cell death through TRAIL-R1 and TRAIL-R2. Despite the fact that these receptors share high structural homologies, induction of apoptosis upon ER stress, cell autonomous motility and invasion ...
    • Trail sensitisation by arsenic trioxide is caspase-8 dependent and involves modulation of death receptor components and akt 

      Szegezdi, E; Cahill, S; Meyer, M; O'Dwyer, M; Samali, A (Springer Nature, 2006-01-24)
      The majority of leukaemic cells are resistant to apoptosis induced by tumour necrosis factor-related apoptosis-inducing ligand (TRAIL). Here, we show that sublethal concentrations of arsenic trioxide (ATO) specifically ...