Now showing items 1-20 of 28

    • An immune-inflammation gene expression signature in prostate tumors of smokers 

      Prueitt, R. L.; Wallace, T. A.; Glynn, S. A.; Yi, M.; Tang, W.; Luo, J.; Dorsey, T. H.; Stagliano, K. E.; Gillespie, J. W.; Hudson, R. S.; Terunuma, A.; Shoe, J. L.; Haines, D. C.; Yfantis, H. G.; Han, M.; Martin, D. N.; Jordan, S. V.; Borin, J. F.; Naslund, M. J.; Alexander, R. B.; Stephens, R. M.; Loffredo, C. A.; Lee, D. H.; Putluri, N.; Sreekumar, A.; Hurwitz, A. A.; Ambs, S. (American Association for Cancer Research (AACR), 2015-12-30)
      Smokers develop metastatic prostate cancer more frequently than nonsmokers, suggesting that a tobacco-derived factor is driving metastatic progression. To identify smoking-induced alterations in human prostate cancer, we ...
    • Carvacrol inhibits osteoclastogenesis and negatively regulates the survival of mature osteoclasts 

      Deepak, Vishwa; Kasonga, Abe; Kruger, Marlena Cathorina; Coetzee, Magdalena (Pharmaceutical Society of Japan, 2016-01-01)
      Bone is a dynamic tissue that undergoes continuous remodeling coupled with the action of osteoblasts and osteoclasts. Osteoclast activity is elevated during osteoporosis and periodontitis resulting in excessive loss of ...
    • Caspases as therapeutic targets 

      Howley, B.; Fearnhead, H.O. (Wiley-Blackwell, 2008-09-01)
      The development of small molecules to modulate caspase activity offers a novel therapeutic strategy in the treatment of apoptosis-related and inflammatory diseases. Caspases are key mediators of apoptosis and inflammation; ...
    • Dr4-selective tumor necrosis factor-related apoptosis-inducing ligand (trail) variants obtained by structure-based design 

      Tur, Vicente; van der Sloot, Almer M.; Reis, Carlos R.; Szegezdi, Eva; Cool, Robbert H.; Samali, Afshin; Serrano, Luis; Quax, Wim J. (American Society for Biochemistry & Molecular Biology (ASBMB), 2008-05-12)
      Tumor necrosis factor-related apoptosis-inducing ligand ( TRAIL) is a potential anticancer agent that selectively induces apoptosis in a variety of cancer cells by interacting with death receptors DR4 and DR5. TRAIL can ...
    • Gene expression profiles of no- and hno-donor treated breast cancer cells: insights into tumor response and resistance pathways 

      Cheng, Robert Y.S.; Basudhar, Debashree; Ridnour, Lisa A.; Heinecke, Julie L.; Kesarwala, Aparna H.; Glynn, Sharon; Switzer, Christopher H.; Ambs, Stefan; Miranda, Katrina M.; Wink, David A. (Elsevier BV, 2014-12-01)
      Nitric oxide (NO) synthase 2 (NOS2), a major inflammatory protein, modulates disease progression via NO in a number of pathologies, including cancer. The role of NOS2-derived NO is not only flux-dependent, which is higher ...
    • Hepatitis b and c virus-induced hepatitis: apoptosis, autophagy, and unfolded protein response 

      Yeganeh, Behzad (Baishideng Publishing Group Inc., 2015-01-01)
      AIM: To investigate the co-incidence of apoptosis, autophagy, and unfolded protein response (UPR) in hepatitis B (HBV) and C (HCV) infected hepatocytes. METHODS: We performed immunofluorescence confocal microscopy on 10 ...
    • Host recognition of bacterial muramyl dipeptide mediated through nod2 

      Inohara, Naohiro; Ogura, Yasunori; Fontalba, Ana; Gutierrez, Olga; Pons, Fernando; Crespo, Javier; Fukase, Koichi; Inamura, Seiichi; Kusumoto, Shoichi; Hashimoto, Masahito; Foster, Simon J.; Moran, Anthony P.; Fernandez-Luna, Jose L.; Nuñez, Gabriel (American Society for Biochemistry & Molecular Biology (ASBMB), 2003-01-04)
      NOD2, a protein associated with susceptibility to Crohn's disease, confers responsiveness to bacterial preparations of lipopolysaccharide and peptidoglycan, but the precise moiety recognized remains elusive. Biochemical ...
    • Hypercapnia induces cleavage and nuclear localization of relb protein, giving insight into co2sensing and signaling 

      Oliver, Kathryn M.; Lenihan, Colin R.; Bruning, Ulrike; Cheong, Alex; Laffey, John G.; McLoughlin, Paul; Taylor, Cormac T.; Cummins, Eoin P. (American Society for Biochemistry & Molecular Biology (ASBMB), 2012-03-06)
      Carbon dioxide (CO2) is increasingly being appreciated as an intracellular signaling molecule that affects inflammatory and immune responses. Elevated arterial CO2 (hypercapnia) is encountered in a range of clinical ...
    • Impact of inducible nitric oxide synthase (inos) expression on triple negative breast cancer outcome and activation of egfr and erk signaling pathways 

      Garrido, Pablo; Shalaby, Aliaa; Walsh, Elaine M.; Keane, Nessa; Webber, Mark; Keane, Maccon; Sullivan, Francis J; Kerin, Michael J.; Callagy, Grace; Ryan, Aideen E.; Glynn, Sharon A. (Impact Journals, LLC, 2017-07-26)
      Inflammation is implicated in triple negative breast cancer (TNBC) progression. TNBC carries a worse prognosis than other breast cancer subtypes, and with the clinical and molecular heterogeneity of TNBC, there is a lack ...
    • Impact ofhelicobacter pylorion the healing process of the gastric barrier 

      Mnich, Eliza; Kowalewicz-Kulbat, Magdalena; Sicińska, Paulina; Hinc, Krzysztof; Obuchowski, Michał; Gajewski, Adrian; Moran, Anthony P; Chmiela, Magdalena (Baishideng Publishing Group Inc., 2016-01-01)
      AIM To determine the impact of selected well defined Helicobacter pylori (H. pylori) antigens on gastric barrier cell turnover. METHODS In this study, using two cellular models of gastric epithelial cells and fibroblasts, ...
    • Mesenchymal stem cells and osteoarthritis: remedy or accomplice? 

      Coleman, Cynthia M.; Curtin, Caroline; Barry, Frank P.; O'Flatharta, Cathal; Murphy, J. Mary (Mary Ann Liebert Inc, 2010-10-01)
      Multipotent mesenchymal stromal or stem cells (MSCs) are likely to be agents of connective tissue homeostasis and repair. Because the hallmark of osteoarthritis (OA) is degeneration and failure to repair connective tissues ...
    • Mesenchymal stem cells in rheumatoid synovium: enumeration and functional assessment in relation to synovial inflammation level 

      Jones, E; Churchman, S M; English, A; Buch, M H; Horner, E A; Burgoyne, C H; Reece, R; Kinsey, S; Emery, P; McGonagle, D; Ponchel, F (BMJ, 2009-04-02)
      Objective: Achieving joint regeneration in rheumatoid arthritis (RA) represents a future challenge. Autologous synovial mesenchymal stem cells (MSCs) could be therapeutically exploited. However, the inflammatory milieu in ...
    • Mesenchymal stromal cells (mscs) and colorectal cancer: a troublesome twosome for the anti-tumour immune response? 

      O’Malley, Grace; Heijltjes, Madelon; Houston, Aileen M.; Rani, Sweta; Ritter, Thomas; Egan, Laurence J.; Ryan, Aideen E. (Impact Journals, LLC, 2016-08-17)
      The tumour microenvironment (TME) is an important factor in determining the growth and metastasis of colorectal cancer, and can aid tumours by both establishing an immunosuppressive milieu, allowing the tumour avoid immune ...
    • Mnsod protects colorectal cancer cells from trail-induced apoptosis by inhibition of smac/diablo release 

      Mohr, A; Büneker, C; Gough, R P; Zwacka, R M (Springer Nature, 2007-07-23)
      The mitochondrial enzyme manganese superoxide dismutase (MnSOD) has been shown to have two faces with regard to its role in tumor development. On the one side, it is well documented that overexpression of MnSOD slows down ...
    • Negative energy balance and hepatic gene expression patterns in high-yielding dairy cows during the early postpartum period: a global approach 

      McCarthy, S. D.; Waters, S. M.; Kenny, D. A.; Diskin, M. G.; Fitzpatrick, R.; Patton, J.; Wathes, D. C.; Morris, D. G. (American Physiological Society, 2010-08-17)
      McCarthy SD, Waters SM, Kenny DA, Diskin MG, Fitzpatrick R, Patton J, Wathes DC, Morris DG. Negative energy balance and hepatic gene expression patterns in high-yielding dairy cows during the early postpartum period: a ...
    • Rapid and efficient cancer cell killing mediated by high-affinity death receptor homotrimerizing trail variants 

      Reis, C R; van der Sloot, A M; Natoni, A; Szegezdi, E; Setroikromo, R; Meijer, M; Sjollema, K; Stricher, F; Cool, R H; Samali, A; Serrano, L; Quax, W J (Springer Nature, 2010-10-01)
      The tumour necrosis factor family member TNF-related apoptosis-inducing ligand (TRAIL) selectively induces apoptosis in a variety of cancer cells through the activation of death receptors 4 (DR4) and 5 (DR5) and is considered ...
    • Redox homeostasis and age-related deficits in neuromuscular integrity and function 

      Sakellariou, Giorgos K.; Lightfoot, Adam P.; Earl, Kate E.; Stofanko, Martin; McDonagh, Brian (Wiley-Blackwell, 2017-07-26)
      Skeletal muscle is a major site of metabolic activity and is the most abundant tissue in the human body. Age-related muscle atrophy (sarcopenia) and weakness, characterized by progressive loss of lean muscle mass and ...
    • Regulatory regions and critical residues of nod2 involved in muramyl dipeptide recognition 

      Tanabe, Tsuyoshi; Chamaillard, Mathias; Ogura, Yasunori; Zhu, Li; Qiu, Su; Masumoto, Junya; Ghosh, Partho; Moran, Anthony; Predergast, Martina M; Tromp, Gerard; Williams, Charlene J; Inohara, Naohiro; Núñez, Gabriel (Wiley-Blackwell, 2004-03-25)
      Multiple genetic variants of CARD15/NOD2 have been associated with susceptibility to Crohn's disease and Blau syndrome. NOD2 recognizes muramyl dipeptide (MDP) derived from bacterial peptidoglycan (PGN), but the molecular ...
    • Ripk1 promotes death receptor-independent caspase-8-mediated apoptosis under unresolved er stress conditions 

      Estornes, Y; Aguileta, M A; Dubuisson, C; De Keyser, J; Goossens, V; Kersse, K; Samali, A; Vandenabeele, P; Bertrand, M J M (Springer Nature, 2014-12-04)
      Accumulation of unfolded proteins in the endoplasmic reticulum (ER) causes ER stress and results in the activation of the unfolded protein response (UPR), which aims at restoring ER homeostasis. However, when the stress ...
    • The anti-inflammatory effect of algae-derived lipid extracts on lipopolysaccharide (lps)-stimulated human thp-1 macrophages 

      Robertson, Ruairi; Guihéneuf, Freddy; Bahar, Bojlul; Schmid, Matthias; Stengel, Dagmar; Fitzgerald, Gerald; Ross, R.; Stanton, Catherine (MDPI AG, 2015-08-20)
      Algae contain a number of anti-inflammatory bioactive compounds such as omega-3 polyunsaturated fatty acids (n-3 PUFA) and chlorophyll a, hence as dietary ingredients, their extracts may be effective in chronic inflammation-linked ...