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  • Replication stress is a potent driver of functional decline in ageing haematopoietic stem cells 

    Flach, Johanna; Bakker, Sietske T.; Mohrin, Mary; Conroy, Pauline C.; Pietras, Eric M.; Reynaud, Damien; Alvarez, Silvia; Diolaiti, Morgan E.; Ugarte, Fernando; Forsberg, E. Camilla; Le Beau, Michelle M.; Stohr, Bradley A.; Méndez, Juan; Morrison, Ciaran G.; Passegué, Emmanuelle (Springer Nature, 2014-07-30)
    Haematopoietic stem cells (HSCs) self-renew for life, thereby making them one of the few blood cells that truly age(1,2). Paradoxically, although HSCs numerically expand with age, their functional activity declines over ...