Now showing items 1-4 of 4

  • A stromal cell free culture system generates mouse pro-t cells that can reconstitute t-cell compartments in vivo 

    Gehre, Nadine; Nusser, Anja; von Muenchow, Lilly; Tussiwand, Roxane; Engdahl, Corinne; Capoferri, Giuseppina; Bosco, Nabil; Ceredig, Rhodri; Rolink, Antonius G. (Wiley-Blackwell, 2014-12-16)
    T-cell lymphopenia following BM transplantation or diseases such as AIDS result in immunodeficiency. Novel approaches to ameliorate this situation are urgently required. Herein, we describe a novel stromal cell free culture ...
  • Dn2 thymocytes activate a specific robust dna damage response to ionizing radiation-induced dna double-strand breaks 

    Calvo-Asensio, Irene; Sugrue, Tara; Bosco, Nabil; Rolink, Antonius; Ceredig, Rhodri (Frontiers Media SA, 2018-06-11)
    For successful bone marrow transplantation (BMT), a preconditioning regime involving chemo and radiotherapy is used that results in DNA damage to both hematopoietic and stromal elements. Following radiation exposure, it ...
  • Identification of 15 new psoriasis susceptibility loci highlights the role of innate immunity 

    Tsoi, Lam C; Spain, Sarah L; Knight, Jo; Ellinghaus, Eva; Stuart, Philip E; Capon, Francesca; Ding, Jun; Li, Yanming; Tejasvi, Trilokraj; Gudjonsson, Johann E; Kang, Hyun M; Allen, Michael H; McManus, Ross; Novelli, Giuseppe; Samuelsson, Lena; Schalkwijk, Joost; Ståhle, Mona; Burden, A David; Smith, Catherine H; Cork, Michael J; Estivill, Xavier; Bowcock, Anne M; Krueger, Gerald G; Weger, Wolfgang; Worthington, Jane; Tazi-Ahnini, Rachid; Nestle, Frank O; Hayday, Adrian; Hoffmann, Per; Winkelmann, Juliane; Wijmenga, Cisca; Langford, Cordelia; Edkins, Sarah; Andrews, Robert; Blackburn, Hannah; Strange, Amy; Band, Gavin; Pearson, Richard D; Vukcevic, Damjan; Spencer, Chris C A; Deloukas, Panos; Mrowietz, Ulrich; Schreiber, Stefan; Weidinger, Stephan; Koks, Sulev; Kingo, Külli; Esko, Tonu; Metspalu, Andres; Lim, Henry W; Voorhees, John J; Weichenthal, Michael; Wichmann, H Erich; Chandran, Vinod; Rosen, Cheryl F; Rahman, Proton; Gladman, Dafna D; Griffiths, Christopher E M; Reis, Andre; Kere, Juha; Duffin, Kristina Callis; Helms, Cindy; Goldgar, David; Li, Yun; Paschall, Justin; Malloy, Mary J; Pullinger, Clive R; Kane, John P; Gardner, Jennifer; Perlmutter, Amy; Miner, Andrew; Feng, Bing Jian; Hiremagalore, Ravi; Ike, Robert W; Christophers, Enno; Henseler, Tilo; Ruether, Andreas; Schrodi, Steven J; Prahalad, Sampath; Guthery, Stephen L; Fischer, Judith; Liao, Wilson; Kwok, Pui; Menter, Alan; Lathrop, G Mark; Wise, C; Begovich, Ann B; Onoufriadis, Alexandros; Weale, Michael E; Hofer, Angelika; Salmhofer, Wolfgang; Wolf, Peter; Kainu, Kati; Saarialho-Kere, Ulpu; Suomela, Sari; Badorf, Petra; Hüffmeier, Ulrike; Kurrat, Werner; Küster, Wolfgang; Lascorz, Jesús; Mössner, Rotraut; Schürmeier-Horst, Funda; Ständer, Markward; Traupe, Heiko; Bergboer, Judith G M; Heijer, Martin den; van de Kerkhof, Peter C; Zeeuwen, Patrick L J M; Barnes, Louise; Campbell, Linda E; Cusack, Caitriona; Coleman, Ciara; Conroy, Judith; Ennis, Sean; Fitzgerald, Oliver; Gallagher, Phil; Irvine, Alan D; Kirby, Brian; Markham, Trevor; McLean, W H Irwin; McPartlin, Joe; Rogers, Sarah F; Ryan, Anthony W; Zawirska, Agnieszka; Giardina, Emiliano; Lepre, Tiziana; Perricone, Carlo; Martín-Ezquerra, Gemma; Pujol, Ramon M; Riveira-Munoz, Eva; Inerot, Annica; Naluai, Åsa T; Mallbris, Lotus; Wolk, Katarina; Leman, Joyce; Barton, Anne; Warren, Richard B; Young, Helen S; Ricano-Ponce, Isis; Trynka, Gosia; Pellett, Fawnda J; Henschel, Andrew; Aurand, Marin; Bebo, Bruce; Gieger, Christian; Illig, Thomas; Moebus, Susanne; Jöckel, Karl-Heinz; Erbel, Raimund; Donnelly, Peter; Peltonen, Leena; Blackwell, Jenefer M; Bramon, Elvira; Brown, Matthew A; Casas, Juan P; Corvin, Aiden; Craddock, Nicholas; Duncanson, Audrey; Jankowski, Janusz; Markus, Hugh S; Mathew, Christopher G; McCarthy, Mark I; Palmer, Colin N A; Plomin, Robert; Rautanen, Anna; Sawcer, Stephen J; Samani, Nilesh; Viswanathan, Ananth C; Wood, Nicholas W; Bellenguez, Céline; Freeman, Colin; Hellenthal, Garrett; Giannoulatou, Eleni; Pirinen, Matti; Su, Zhan; Hunt, Sarah E; Gwilliam, Rhian; Bumpstead, Suzannah J; Dronov, Serge; Gillman, Matthew; Gray, Emma; Hammond, Naomi; Jayakumar, Alagurevathi; McCann, Owen T; Liddle, Jennifer; Perez, Marc L; Potter, Simon C; Ravindrarajah, Radhi; Ricketts, Michelle; Waller, Matthew; Weston, Paul; Widaa, Sara; Whittaker, Pamela; Nair, Rajan P; Franke, Andre; Barker, Jonathan N W N; Abecasis, Goncalo R; Elder, James T; Trembath, Richard C (Springer Nature, 2012-11-11)
    To gain further insight into the genetic architecture of psoriasis, we conducted a meta-analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets genotyped on the Immunochip, including 10,588 cases ...
  • The pretcr-dependent dn3 to dp transition requires notch signaling, is improved by cxcl12 signaling and is inhibited by il-7 signaling 

    Tussiwand, Roxane; Engdahl, Corinne; Gehre, Nadine; Bosco, Nabil; Ceredig, Rod; Rolink, Antonius G. (Wiley-Blackwell, 2011-10-04)
    The requirement for Notch signaling during T-cell development has been extensively studied. Nevertheless, the developmental stage at which it is required and whether additional signaling pathways are needed are still poorly ...