Now showing items 1-4 of 4

  • Functional expression of fasciola hepatica cathepsin l1 in saccharomyces cerevisiae 

    Roche, Leda; Dowd, Andrew J.; Tort, Jose; McGonigle, Sharon; McSweeney, Aengus; Curley, G. Paul; Ryan, Thecla; Dalton, John P. (Wiley-Blackwell, 1997-04-15)
    A cDNA encoding the complete precursor of a Fasciola hepatica cathepsin L protease was isolated and sequenced. Functionally active enzyme was expressed and secreted by Saccharomyces cerevisiae transformed with a plasmid ...
  • Intron length coevolution across mammalian genomes 

    Keane, Peter A.; Seoighe, Cathal (Oxford University Press (OUP), 2016-08-22)
    Although they do not contribute directly to the proteome, introns frequently contain regulatory elements and can extend the protein coding potential of the genome through alternative splicing. For some genes, the contribution ...
  • Rapid unwinding of triplet repeat hairpins by srs2 helicase of saccharomyces cerevisiae 

    Dhar, Alok; Lahue, Robert S. (Oxford University Press (OUP), 2008-04-25)
    Expansions of trinucleotide repeats cause at least 15 heritable human diseases. Single-stranded triplet repeat DNA in vitro forms stable hairpins in a sequence-dependent manner that correlates with expansion risk in vivo. ...
  • Viral proteins as a potential driver of histone depletion in dinoflagellates 

    Irwin, Nicholas A. T.; Martin, Benjamin J. E.; Young, Barry P.; Browne, Martin J. G.; Flaus, Andrew; Loewen, Christopher J. R.; Keeling, Patrick J.; Howe, LeAnn J. (Springer Nature, 2018-04-18)
    Within canonical eukaryotic nuclei, DNA is packaged with highly conserved histone proteins into nucleosomes, which facilitate DNA condensation and contribute to genomic regulation. Yet the dinoflagellates, a group of ...