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dc.contributor.authorBano, Kiran
dc.contributor.authorRusling, James F.
dc.date.accessioned2018-09-20T16:00:27Z
dc.date.available2018-09-20T16:00:27Z
dc.date.issued2016-06-01
dc.identifier.citationBano, Kiran; Rusling, James F. (2016). Electrochemiluminescence arrays for studies of metabolite-related toxicity. Electroanalysis 28 (11), 2636-2643
dc.identifier.issn1040-0397
dc.identifier.urihttp://hdl.handle.net/10379/10342
dc.description.abstractThis article reviews recent progress from our laboratory in electrochemiluminescence (ECL) arrays designed for screening toxicity-related chemistry of chemical and drug candidates. Cytochrome P450s and metabolic bioconjugation enzymes convert lipophilic chemicals in our bodies by oxidation and bioconjugation that can lead to toxic metabolites. DNA can be used as an easily measurable toxicity-related endpoint, targeting DNA oxidation and addcut formation with metabolites. ECL using guanosines in the DNA strands as co-reactants have been used in high throughput arrays utilizing DNA-enzyme films fabricated layer-by-layer. This review describes approaches developed to provide new high throughput ECL arrays to aid in toxicity assessment for drug and chemical product development.
dc.publisherWiley-Blackwell
dc.relation.ispartofElectroanalysis
dc.subjectmetabolites
dc.subjecttoxicity chemistry
dc.subjectelectrochemiluminescence
dc.subjectDNA arrays
dc.subjectDNA damage
dc.subjectcytochrome p450s
dc.subjectlayer-by-layer
dc.subjectDNA-damage
dc.subjectcytochrome-p450 enzymes
dc.subjectoxidative stress
dc.subjectultrathin films
dc.subjectchemical toxicity
dc.subjectsensor
dc.subjectelectrochemistry
dc.subjectmyoglobin
dc.titleElectrochemiluminescence arrays for studies of metabolite-related toxicity
dc.typeArticle
dc.identifier.doi10.1002/elan.201600207
dc.local.publishedsourcehttp://europepmc.org/articles/pmc5459409?pdf=render
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