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dc.contributor.authorDaly, W.
dc.contributor.authorYao, L.
dc.contributor.authorZeugolis, D.
dc.contributor.authorWindebank, A.
dc.contributor.authorPandit, A.
dc.date.accessioned2018-09-20T16:04:59Z
dc.date.available2018-09-20T16:04:59Z
dc.date.issued2011-11-16
dc.identifier.citationDaly, W. Yao, L.; Zeugolis, D.; Windebank, A.; Pandit, A. (2011). A biomaterials approach to peripheral nerve regeneration: bridging the peripheral nerve gap and enhancing functional recovery. Journal of The Royal Society Interface 9 (67), 202-221
dc.identifier.issn1742-5689,1742-5662
dc.identifier.urihttp://hdl.handle.net/10379/11039
dc.description.abstractMicrosurgical techniques for the treatment of large peripheral nerve injuries (such as the gold standard autograft) and its main clinically approved alternative-hollow nerve guidance conduits (NGCs)-have a number of limitations that need to be addressed. NGCs, in particular, are limited to treating a relatively short nerve gap (4 cm in length) and are often associated with poor functional recovery. Recent advances in biomaterials and tissue engineering approaches are seeking to overcome the limitations associated with these treatment methods. This review critically discusses the advances in biomaterial-based NGCs, their limitations and where future improvements may be required. Recent developments include the incorporation of topographical guidance features and/or intraluminal structures, which attempt to guide Schwann cell (SC) migration and axonal regrowth towards their distal targets. The use of such strategies requires consideration of the size and distribution of these topographical features, as well as a suitable surface for cell-material interactions. Likewise, cellular and molecular-based therapies are being considered for the creation of a more conductive nerve microenvironment. For example, hurdles associated with the short half-lives and low stability of molecular therapies are being surmounted through the use of controlled delivery systems. Similarly, cells (SCs, stem cells and genetically modified cells) are being delivered with biomaterial matrices in attempts to control their dispersion and to facilitate their incorporation within the host regeneration process. Despite recent advances in peripheral nerve repair, there are a number of key factors that need to be considered in order for these new technologies to reach the clinic.
dc.publisherThe Royal Society
dc.relation.ispartofJournal of The Royal Society Interface
dc.subjectperipheral nerve conduit
dc.subjecttopographical guidance
dc.subjectmolecular therapy
dc.subjectschwann cells
dc.subjectstem cells
dc.subjectneurotrophic factors
dc.subjectmesenchymal stem-cells
dc.subjectglycolic acid) conduits
dc.subjectcross-linked gelatin
dc.subjectin-vivo evaluation
dc.subjectschwann-cells
dc.subjectneurotrophic factor
dc.subjectguidance channels
dc.subjectgrowth-factor
dc.subjectaxonal regeneration
dc.subjectcollagen filaments
dc.titleA biomaterials approach to peripheral nerve regeneration: bridging the peripheral nerve gap and enhancing functional recovery
dc.typeArticle
dc.identifier.doi10.1098/rsif.2011.0438
dc.local.publishedsourcehttp://rsif.royalsocietypublishing.org/content/royinterface/9/67/202.full.pdf
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