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dc.contributor.authorFlaus, Andrew
dc.contributor.authorOwen-Hughes, Tom
dc.date.accessioned2018-09-20T16:08:26Z
dc.date.available2018-09-20T16:08:26Z
dc.date.issued2011-09-08
dc.identifier.citationFlaus, Andrew; Owen-Hughes, Tom (2011). Mechanisms for atp-dependent chromatin remodelling: the means to the end. FEBS Journal 278 (19), 3579-3595
dc.identifier.issn1742-464X
dc.identifier.urihttp://hdl.handle.net/10379/11511
dc.description.abstractChromatin remodelling is the ATP-dependent change in nucleosome organisation driven by Snf2 family ATPases. The biochemistry of this process depends on the behaviours of ATP-dependent motor proteins and their dynamic nucleosome substrates, which brings significant technical and conceptual challenges. Steady progress has been made in characterising the polypeptides of which these enzymes are comprised. Divergence in the sequences of different subfamilies of Snf2-related proteins suggests that the motors are adapted for different functions. Recently, structural insights have suggested that the Snf2 ATPase acts as a context-sensitive DNA translocase. This may have arisen as a means to enable efficient access to DNA in the high density of the eukaryotic nucleus. How the enzymes engage nucleosomes and how the network of noncovalent interactions within the nucleosome respond to the force applied remains unclear, and it remains prudent to recognise the potential for both DNA distortions and dynamics within the underlying histone octamer structure.
dc.publisherWiley-Blackwell
dc.relation.ispartofFEBS Journal
dc.subjectatp dependent chromatin remodelling
dc.subjectchd1
dc.subjecthistone
dc.subjectiswi
dc.subjectnucleosome
dc.subjectsnf2
dc.subjectswi/snf
dc.subjectyeast swi/snf complex
dc.subjectnucleotide excision-repair
dc.subjectsaccharomyces-cerevisiae
dc.subjectrna-polymerase
dc.subjectsnf2 family
dc.subjectin-vivo
dc.subjectisw2-nucleosome complex
dc.subjectnucleosome mobilization
dc.subjecthistone modifications
dc.subjectfunctional-analysis
dc.titleMechanisms for atp-dependent chromatin remodelling: the means to the end
dc.typeArticle
dc.identifier.doi10.1111/j.1742-4658.2011.08281.x
dc.local.publishedsourcehttp://onlinelibrary.wiley.com/doi/10.1111/j.1742-4658.2011.08281.x/pdf
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