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dc.contributor.authorGarcia-Closas, Montserrat
dc.contributor.authorCouch, Fergus J
dc.contributor.authorLindstrom, Sara
dc.contributor.authorMichailidou, Kyriaki
dc.contributor.authorSchmidt, Marjanka K
dc.contributor.authorBrook, Mark N
dc.contributor.authorOrr, Nick
dc.contributor.authorRhie, Suhn Kyong
dc.contributor.authorRiboli, Elio
dc.contributor.authorFeigelson, Heather S
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorBuring, Julie E
dc.contributor.authorEccles, Diana
dc.contributor.authorMiron, Penelope
dc.contributor.authorFasching, Peter A
dc.contributor.authorBrauch, Hiltrud
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorCarpenter, Jane
dc.contributor.authorGodwin, Andrew K
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorGiles, Graham G
dc.contributor.authorCox, Angela
dc.contributor.authorHopper, John L
dc.contributor.authorBolla, Manjeet K
dc.contributor.authorWang, Qin
dc.contributor.authorDennis, Joe
dc.contributor.authorDicks, Ed
dc.contributor.authorHowat, Will J
dc.contributor.authorSchoof, Nils
dc.contributor.authorBojesen, Stig E
dc.contributor.authorLambrechts, Diether
dc.contributor.authorBroeks, Annegien
dc.contributor.authorAndrulis, Irene L
dc.contributor.authorGuénel, Pascal
dc.contributor.authorBurwinkel, Barbara
dc.contributor.authorSawyer, Elinor J
dc.contributor.authorHollestelle, Antoinette
dc.contributor.authorFletcher, Olivia
dc.contributor.authorWinqvist, Robert
dc.contributor.authorBrenner, Hermann
dc.contributor.authorMannermaa, Arto
dc.contributor.authorHamann, Ute
dc.contributor.authorMeindl, Alfons
dc.contributor.authorLindblom, Annika
dc.contributor.authorZheng, Wei
dc.contributor.authorDevillee, Peter
dc.contributor.authorGoldberg, Mark S
dc.contributor.authorLubinski, Jan
dc.contributor.authorKristensen, Vessela
dc.contributor.authorSwerdlow, Anthony
dc.contributor.authorAnton-Culver, Hoda
dc.contributor.authorDörk, Thilo
dc.contributor.authorMuir, Kenneth
dc.contributor.authorMatsuo, Keitaro
dc.contributor.authorWu, Anna H
dc.contributor.authorRadice, Paolo
dc.contributor.authorTeo, Soo Hwang
dc.contributor.authorShu, Xiao-Ou
dc.contributor.authorBlot, William
dc.contributor.authorKang, Daehee
dc.contributor.authorHartman, Mikael
dc.contributor.authorSangrajrang, Suleeporn
dc.contributor.authorShen, Chen-Yang
dc.contributor.authorSouthey, Melissa C
dc.contributor.authorPark, Daniel J
dc.contributor.authorHammet, Fleur
dc.contributor.authorStone, Jennifer
dc.contributor.authorVeer, Laura J Van't
dc.contributor.authorRutgers, Emiel J
dc.contributor.authorLophatananon, Artitaya
dc.contributor.authorStewart-Brown, Sarah
dc.contributor.authorSiriwanarangsan, Pornthep
dc.contributor.authorPeto, Julian
dc.contributor.authorSchrauder, Michael G
dc.contributor.authorEkici, Arif B
dc.contributor.authorBeckmann, Matthias W
dc.contributor.authordos Santos Silva, Isabel
dc.contributor.authorJohnson, Nichola
dc.contributor.authorWarren, Helen
dc.contributor.authorTomlinson, Ian
dc.contributor.authorKerin, Michael J
dc.contributor.authorMiller, Nicola
dc.contributor.authorMarme, Federick
dc.contributor.authorSchneeweiss, Andreas
dc.contributor.authorSohn, Christof
dc.contributor.authorTruong, Therese
dc.contributor.authorLaurent-Puig, Pierre
dc.contributor.authorKerbrat, Pierre
dc.contributor.authorNordestgaard, Børge G
dc.contributor.authorNielsen, Sune F
dc.contributor.authorFlyger, Henrik
dc.contributor.authorMilne, Roger L
dc.contributor.authorPerez, Jose Ignacio Arias
dc.contributor.authorMenéndez, Primitiva
dc.contributor.authorMüller, Heiko
dc.contributor.authorArndt, Volker
dc.contributor.authorStegmaier, Christa
dc.contributor.authorLichtner, Peter
dc.contributor.authorLochmann, Magdalena
dc.contributor.authorJustenhoven, Christina
dc.contributor.authorKo, Yon-Dschun
dc.contributor.authorMuranen, Taru A
dc.contributor.authorAittomäki, Kristiina
dc.contributor.authorBlomqvist, Carl
dc.contributor.authorGreco, Dario
dc.contributor.authorHeikkinen, Tuomas
dc.contributor.authorIto, Hidemi
dc.contributor.authorIwata, Hiroji
dc.contributor.authorYatabe, Yasushi
dc.contributor.authorAntonenkova, Natalia N
dc.contributor.authorMargolin, Sara
dc.contributor.authorKataja, Vesa
dc.contributor.authorKosma, Veli-Matti
dc.contributor.authorHartikainen, Jaana M
dc.contributor.authorBalleine, Rosemary
dc.contributor.authorTseng, Chiu-Chen
dc.contributor.authorBerg, David Van Den
dc.contributor.authorStram, Daniel O
dc.contributor.authorNeven, Patrick
dc.contributor.authorDieudonné, Anne-Sophie
dc.contributor.authorLeunen, Karin
dc.contributor.authorRudolph, Anja
dc.contributor.authorNickels, Stefan
dc.contributor.authorFlesch-Janys, Dieter
dc.contributor.authorPeterlongo, Paolo
dc.contributor.authorPeissel, Bernard
dc.contributor.authorBernard, Loris
dc.contributor.authorOlson, Janet E
dc.contributor.authorWang, Xianshu
dc.contributor.authorStevens, Kristen
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorBaglietto, Laura
dc.contributor.authorMcLean, Catriona
dc.contributor.authorCoetzee, Gerhard A
dc.contributor.authorFeng, Ye
dc.contributor.authorHenderson, Brian E
dc.contributor.authorSchumacher, Fredrick
dc.contributor.authorBogdanova, Natalia V
dc.contributor.authorLabrèche, France
dc.contributor.authorDumont, Martine
dc.contributor.authorYip, Cheng Har
dc.contributor.authorTaib, Nur Aishah Mohd
dc.contributor.authorCheng, Ching-Yu
dc.contributor.authorShrubsole, Martha
dc.contributor.authorLong, Jirong
dc.contributor.authorPylkäs, Katri
dc.contributor.authorJukkola-Vuorinen, Arja
dc.contributor.authorKauppila, Saila
dc.contributor.authorKnight, Julia A
dc.contributor.authorGlendon, Gord
dc.contributor.authorMulligan, Anna Marie
dc.contributor.authorTollenaar, Robertus A E M
dc.contributor.authorSeynaeve, Caroline M
dc.contributor.authorKriege, Mieke
dc.contributor.authorHooning, Maartje J
dc.contributor.authorvan den Ouweland, Ans M W
dc.contributor.authorvan Deurzen, Carolien H M
dc.contributor.authorLu, Wei
dc.contributor.authorGao, Yu-Tang
dc.contributor.authorCai, Hui
dc.contributor.authorBalasubramanian, Sabapathy P
dc.contributor.authorCross, Simon S
dc.contributor.authorReed, Malcolm W R
dc.contributor.authorSignorello, Lisa
dc.contributor.authorCai, Qiuyin
dc.contributor.authorShah, Mitul
dc.contributor.authorMiao, Hui
dc.contributor.authorChan, Ching Wan
dc.contributor.authorChia, Kee Seng
dc.contributor.authorJakubowska, Anna
dc.contributor.authorJaworska, Katarzyna
dc.contributor.authorDurda, Katarzyna
dc.contributor.authorHsiung, Chia-Ni
dc.contributor.authorWu, Pei-Ei
dc.contributor.authorYu, Jyh-Cherng
dc.contributor.authorAshworth, Alan
dc.contributor.authorJones, Michael
dc.contributor.authorTessier, Daniel C
dc.contributor.authorGonzález-Neira, Anna
dc.contributor.authorPita, Guillermo
dc.contributor.authorAlonso, M Rosario
dc.contributor.authorVincent, Daniel
dc.contributor.authorBacot, Francois
dc.contributor.authorAmbrosone, Christine B
dc.contributor.authorBandera, Elisa V
dc.contributor.authorJohn, Esther M
dc.contributor.authorChen, Gary K
dc.contributor.authorHu, Jennifer J
dc.contributor.authorRodriguez-Gil, Jorge L
dc.contributor.authorBernstein, Leslie
dc.contributor.authorPress, Michael F
dc.contributor.authorZiegler, Regina G
dc.contributor.authorMillikan, Robert M
dc.contributor.authorDeming-Halverson, Sandra L
dc.contributor.authorNyante, Sarah
dc.contributor.authorIngles, Sue A
dc.contributor.authorWaisfisz, Quinten
dc.contributor.authorTsimiklis, Helen
dc.contributor.authorMakalic, Enes
dc.contributor.authorSchmidt, Daniel
dc.contributor.authorBui, Minh
dc.contributor.authorGibson, Lorna
dc.contributor.authorMüller-Myhsok, Bertram
dc.contributor.authorSchmutzler, Rita K
dc.contributor.authorHein, Rebecca
dc.contributor.authorDahmen, Norbert
dc.contributor.authorBeckmann, Lars
dc.contributor.authorAaltonen, Kirsimari
dc.contributor.authorCzene, Kamila
dc.contributor.authorIrwanto, Astrid
dc.contributor.authorLiu, Jianjun
dc.contributor.authorTurnbull, Clare
dc.contributor.authorRahman, Nazneen
dc.contributor.authorMeijers-Heijboer, Hanne
dc.contributor.authorUitterlinden, Andre G
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorOlswold, Curtis
dc.contributor.authorSlager, Susan
dc.contributor.authorPilarski, Robert
dc.contributor.authorAdemuyiwa, Foluso
dc.contributor.authorKonstantopoulou, Irene
dc.contributor.authorMartin, Nicholas G
dc.contributor.authorMontgomery, Grant W
dc.contributor.authorSlamon, Dennis J
dc.contributor.authorRauh, Claudia
dc.contributor.authorLux, Michael P
dc.contributor.authorJud, Sebastian M
dc.contributor.authorBruning, Thomas
dc.contributor.authorWeaver, JoEllen
dc.contributor.authorSharma, Priyanka
dc.contributor.authorPathak, Harsh
dc.contributor.authorTapper, Will
dc.contributor.authorGerty, Sue
dc.contributor.authorDurcan, Lorraine
dc.contributor.authorTrichopoulos, Dimitrios
dc.contributor.authorTumino, Rosario
dc.contributor.authorPeeters, Petra H
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorCampa, Daniele
dc.contributor.authorCanzian, Federico
dc.contributor.authorWeiderpass, Elisabete
dc.contributor.authorJohansson, Mattias
dc.contributor.authorKhaw, Kay-Tee
dc.contributor.authorTravis, Ruth
dc.contributor.authorClavel-Chapelon, Françoise
dc.contributor.authorKolonel, Laurence N
dc.contributor.authorChen, Constance
dc.contributor.authorBeck, Andy
dc.contributor.authorHankinson, Susan E
dc.contributor.authorBerg, Christine D
dc.contributor.authorHoover, Robert N
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorFigueroa, Jonine D
dc.contributor.authorChasman, Daniel I
dc.contributor.authorGaudet, Mia M
dc.contributor.authorDiver, W Ryan
dc.contributor.authorWillett, Walter C
dc.contributor.authorHunter, David J
dc.contributor.authorSimard, Jacques
dc.contributor.authorBenitez, Javier
dc.contributor.authorDunning, Alison M
dc.contributor.authorSherman, Mark E
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorChanock, Stephen J
dc.contributor.authorHall, Per
dc.contributor.authorPharoah, Paul D P
dc.contributor.authorVachon, Celine
dc.contributor.authorEaston, Douglas F
dc.contributor.authorHaiman, Christopher A
dc.contributor.authorKraft, Peter
dc.date.accessioned2018-09-20T16:08:50Z
dc.date.available2018-09-20T16:08:50Z
dc.date.issued2013-03-27
dc.identifier.citationGarcia-Closas, Montserrat; Couch, Fergus J; Lindstrom, Sara; Michailidou, Kyriaki; Schmidt, Marjanka K; Brook, Mark N; Orr, Nick; Rhie, Suhn Kyong; Riboli, Elio; Feigelson, Heather S; Le Marchand, Loic; Buring, Julie E; Eccles, Diana; Miron, Penelope; Fasching, Peter A; Brauch, Hiltrud; Chang-Claude, Jenny; Carpenter, Jane; Godwin, Andrew K; Nevanlinna, Heli; Giles, Graham G; Cox, Angela; Hopper, John L; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Dicks, Ed; Howat, Will J; Schoof, Nils; Bojesen, Stig E; Lambrechts, Diether; Broeks, Annegien; Andrulis, Irene L; Guénel, Pascal; Burwinkel, Barbara; Sawyer, Elinor J; Hollestelle, Antoinette; Fletcher, Olivia; Winqvist, Robert; Brenner, Hermann; Mannermaa, Arto; Hamann, Ute; Meindl, Alfons; Lindblom, Annika; Zheng, Wei; Devillee, Peter; Goldberg, Mark S; Lubinski, Jan; Kristensen, Vessela; Swerdlow, Anthony; Anton-Culver, Hoda; Dörk, Thilo; Muir, Kenneth; Matsuo, Keitaro; Wu, Anna H; Radice, Paolo; Teo, Soo Hwang; Shu, Xiao-Ou; Blot, William; Kang, Daehee; Hartman, Mikael; Sangrajrang, Suleeporn; Shen, Chen-Yang; Southey, Melissa C; Park, Daniel J; Hammet, Fleur; Stone, Jennifer; Veer, Laura J Van't; Rutgers, Emiel J; Lophatananon, Artitaya; Stewart-Brown, Sarah; Siriwanarangsan, Pornthep; Peto, Julian; Schrauder, Michael G; Ekici, Arif B; Beckmann, Matthias W; dos Santos Silva, Isabel; Johnson, Nichola; Warren, Helen; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Marme, Federick; Schneeweiss, Andreas; Sohn, Christof; Truong, Therese; Laurent-Puig, Pierre; Kerbrat, Pierre; Nordestgaard, Børge G; Nielsen, Sune F; Flyger, Henrik; Milne, Roger L; Perez, Jose Ignacio Arias; Menéndez, Primitiva; Müller, Heiko; Arndt, Volker; Stegmaier, Christa; Lichtner, Peter; Lochmann, Magdalena; Justenhoven, Christina; Ko, Yon-Dschun; Muranen, Taru A; Aittomäki, Kristiina; Blomqvist, Carl; Greco, Dario; Heikkinen, Tuomas; Ito, Hidemi; Iwata, Hiroji; Yatabe, Yasushi; Antonenkova, Natalia N; Margolin, Sara; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Balleine, Rosemary; Tseng, Chiu-Chen; Berg, David Van Den; Stram, Daniel O; Neven, Patrick; Dieudonné, Anne-Sophie; Leunen, Karin; Rudolph, Anja; Nickels, Stefan; Flesch-Janys, Dieter; Peterlongo, Paolo; Peissel, Bernard; Bernard, Loris; Olson, Janet E; Wang, Xianshu; Stevens, Kristen; Severi, Gianluca; Baglietto, Laura; McLean, Catriona; Coetzee, Gerhard A; Feng, Ye; Henderson, Brian E; Schumacher, Fredrick; Bogdanova, Natalia V; Labrèche, France; Dumont, Martine; Yip, Cheng Har; Taib, Nur Aishah Mohd; Cheng, Ching-Yu; Shrubsole, Martha; Long, Jirong; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Kauppila, Saila; Knight, Julia A; Glendon, Gord; Mulligan, Anna Marie; Tollenaar, Robertus A E M; Seynaeve, Caroline M; Kriege, Mieke; Hooning, Maartje J; van den Ouweland, Ans M W; van Deurzen, Carolien H M; Lu, Wei; Gao, Yu-Tang; Cai, Hui; Balasubramanian, Sabapathy P; Cross, Simon S; Reed, Malcolm W R; Signorello, Lisa; Cai, Qiuyin; Shah, Mitul; Miao, Hui; Chan, Ching Wan; Chia, Kee Seng; Jakubowska, Anna; Jaworska, Katarzyna; Durda, Katarzyna; Hsiung, Chia-Ni; Wu, Pei-Ei; Yu, Jyh-Cherng; Ashworth, Alan; Jones, Michael; Tessier, Daniel C; González-Neira, Anna; Pita, Guillermo; Alonso, M Rosario; Vincent, Daniel; Bacot, Francois; Ambrosone, Christine B; Bandera, Elisa V; John, Esther M; Chen, Gary K; Hu, Jennifer J; Rodriguez-Gil, Jorge L; Bernstein, Leslie; Press, Michael F; Ziegler, Regina G; Millikan, Robert M; Deming-Halverson, Sandra L; Nyante, Sarah; Ingles, Sue A; Waisfisz, Quinten; Tsimiklis, Helen; Makalic, Enes; Schmidt, Daniel; Bui, Minh; Gibson, Lorna; Müller-Myhsok, Bertram; Schmutzler, Rita K; Hein, Rebecca; Dahmen, Norbert; Beckmann, Lars; Aaltonen, Kirsimari; Czene, Kamila; Irwanto, Astrid; Liu, Jianjun; Turnbull, Clare; Rahman, Nazneen; Meijers-Heijboer, Hanne; Uitterlinden, Andre G; Rivadeneira, Fernando; Olswold, Curtis; Slager, Susan; Pilarski, Robert; Ademuyiwa, Foluso; Konstantopoulou, Irene; Martin, Nicholas G; Montgomery, Grant W; Slamon, Dennis J; Rauh, Claudia; Lux, Michael P; Jud, Sebastian M; Bruning, Thomas; Weaver, JoEllen; Sharma, Priyanka; Pathak, Harsh; Tapper, Will; Gerty, Sue; Durcan, Lorraine; Trichopoulos, Dimitrios; Tumino, Rosario; Peeters, Petra H; Kaaks, Rudolf; Campa, Daniele; Canzian, Federico; Weiderpass, Elisabete; Johansson, Mattias; Khaw, Kay-Tee; Travis, Ruth; Clavel-Chapelon, Françoise; Kolonel, Laurence N; Chen, Constance; Beck, Andy; Hankinson, Susan E; Berg, Christine D; Hoover, Robert N; Lissowska, Jolanta; Figueroa, Jonine D; Chasman, Daniel I; Gaudet, Mia M; Diver, W Ryan; Willett, Walter C; Hunter, David J; Simard, Jacques; Benitez, Javier; Dunning, Alison M; Sherman, Mark E; Chenevix-Trench, Georgia; Chanock, Stephen J; Hall, Per; Pharoah, Paul D P; Vachon, Celine; Easton, Douglas F; Haiman, Christopher A; Kraft, Peter (2013). Genome-wide association studies identify four er negative–specific breast cancer risk loci. Nature Genetics 45 (4), 392-398
dc.identifier.issn1061-4036,1546-1718
dc.identifier.urihttp://hdl.handle.net/10379/11587
dc.description.abstractEstrogen receptor (ER)-negative tumors represent 20-30% of all breast cancers, with a higher proportion occurring in younger women and women of African ancestry. The etiology and clinical behavior of ER-negative tumors are different from those of tumors expressing ER (ER positive), including differences in genetic predisposition. To identify susceptibility loci specific to ER-negative disease, we combined in a metaanalysis 3 genome-wide association studies of 4,193 ER-negative breast cancer cases and 35,194 controls with a series of 40 follow-up studies (6,514 cases and 41,455 controls), genotyped using a custom Illumina array, iCOGS, developed by the Collaborative Oncological Gene-environment Study (COGS). SNPs at four loci, 1q32.1 (MDM4, P= 2.1 x 10(-12) and LGR6, P = 1.4 x 10(-8)), 2p24.1 (P = 4.6 x 10(-8)) and 16q12.2 (FTO, P = 4.0 x 10(-8)), were associated with ER-negative but not ER-positive breast cancer (P> 0.05). These findings provide further evidence for distinct etiological pathways associated with invasive ER-positive and ER-negative breast cancers.
dc.publisherSpringer Nature
dc.relation.ispartofNature Genetics
dc.subjectbody-mass index
dc.subjectcommon variant
dc.subjectsusceptibility
dc.subjectexpression
dc.subjectestrogen
dc.subjectgene
dc.titleGenome-wide association studies identify four er negative–specific breast cancer risk loci
dc.typeArticle
dc.identifier.doi10.1038/ng.2561
dc.local.publishedsourcehttp://eprints.whiterose.ac.uk/110837/1/nihms479348.pdf
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