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dc.contributor.authorGhoussaini, Maya
dc.contributor.authorFletcher, Olivia
dc.contributor.authorMichailidou, Kyriaki
dc.contributor.authorTurnbull, Clare
dc.contributor.authorSchmidt, Marjanka K
dc.contributor.authorDicks, Ed
dc.contributor.authorDennis, Joe
dc.contributor.authorWang, Qin
dc.contributor.authorHumphreys, Manjeet K
dc.contributor.authorLuccarini, Craig
dc.contributor.authorBaynes, Caroline
dc.contributor.authorConroy, Don
dc.contributor.authorMaranian, Melanie
dc.contributor.authorAhmed, Shahana
dc.contributor.authorDriver, Kristy
dc.contributor.authorJohnson, Nichola
dc.contributor.authorOrr, Nicholas
dc.contributor.authordos Santos Silva, Isabel
dc.contributor.authorWaisfisz, Quinten
dc.contributor.authorMeijers-Heijboer, Hanne
dc.contributor.authorUitterlinden, Andre G
dc.contributor.authorRivadeneira, Fernando
dc.contributor.authorHall, Per
dc.contributor.authorCzene, Kamila
dc.contributor.authorIrwanto, Astrid
dc.contributor.authorLiu, Jianjun
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorAittomäki, Kristiina
dc.contributor.authorBlomqvist, Carl
dc.contributor.authorMeindl, Alfons
dc.contributor.authorSchmutzler, Rita K
dc.contributor.authorMüller-Myhsok, Bertram
dc.contributor.authorLichtner, Peter
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorHein, Rebecca
dc.contributor.authorNickels, Stefan
dc.contributor.authorFlesch-Janys, Dieter
dc.contributor.authorTsimiklis, Helen
dc.contributor.authorMakalic, Enes
dc.contributor.authorSchmidt, Daniel
dc.contributor.authorBui, Minh
dc.contributor.authorHopper, John L
dc.contributor.authorApicella, Carmel
dc.contributor.authorPark, Daniel J
dc.contributor.authorSouthey, Melissa
dc.contributor.authorHunter, David J
dc.contributor.authorChanock, Stephen J
dc.contributor.authorBroeks, Annegien
dc.contributor.authorVerhoef, Senno
dc.contributor.authorHogervorst, Frans B L
dc.contributor.authorFasching, Peter A
dc.contributor.authorLux, Michael P
dc.contributor.authorBeckmann, Matthias W
dc.contributor.authorEkici, Arif B
dc.contributor.authorSawyer, Elinor
dc.contributor.authorTomlinson, Ian
dc.contributor.authorKerin, Michael
dc.contributor.authorMarme, Frederik
dc.contributor.authorSchneeweiss, Andreas
dc.contributor.authorSohn, Christof
dc.contributor.authorBurwinkel, Barbara
dc.contributor.authorGuénel, Pascal
dc.contributor.authorTruong, Thérèse
dc.contributor.authorCordina-Duverger, Emilie
dc.contributor.authorMenegaux, Florence
dc.contributor.authorBojesen, Stig E
dc.contributor.authorNordestgaard, Børge G
dc.contributor.authorNielsen, Sune F
dc.contributor.authorFlyger, Henrik
dc.contributor.authorMilne, Roger L
dc.contributor.authorAlonso, M Rosario
dc.contributor.authorGonzález-Neira, Anna
dc.contributor.authorBenítez, Javier
dc.contributor.authorAnton-Culver, Hoda
dc.contributor.authorZiogas, Argyrios
dc.contributor.authorBernstein, Leslie
dc.contributor.authorDur, Christina Clarke
dc.contributor.authorBrenner, Hermann
dc.contributor.authorMüller, Heiko
dc.contributor.authorArndt, Volker
dc.contributor.authorStegmaier, Christa
dc.contributor.authorJustenhoven, Christina
dc.contributor.authorBrauch, Hiltrud
dc.contributor.authorBrüning, Thomas
dc.contributor.authorWang-Gohrke, Shan
dc.contributor.authorEilber, Ursula
dc.contributor.authorDörk, Thilo
dc.contributor.authorSchürmann, Peter
dc.contributor.authorBremer, Michael
dc.contributor.authorHillemanns, Peter
dc.contributor.authorBogdanova, Natalia V
dc.contributor.authorAntonenkova, Natalia N
dc.contributor.authorRogov, Yuri I
dc.contributor.authorKarstens, Johann H
dc.contributor.authorBermisheva, Marina
dc.contributor.authorProkofieva, Darya
dc.contributor.authorKhusnutdinova, Elza
dc.contributor.authorLindblom, Annika
dc.contributor.authorMargolin, Sara
dc.contributor.authorMannermaa, Arto
dc.contributor.authorKataja, Vesa
dc.contributor.authorKosma, Veli-Matti
dc.contributor.authorHartikainen, Jaana M
dc.contributor.authorLambrechts, Diether
dc.contributor.authorYesilyurt, Betul T
dc.contributor.authorFloris, Giuseppe
dc.contributor.authorLeunen, Karin
dc.contributor.authorManoukian, Siranoush
dc.contributor.authorBonanni, Bernardo
dc.contributor.authorFortuzzi, Stefano
dc.contributor.authorPeterlongo, Paolo
dc.contributor.authorCouch, Fergus J
dc.contributor.authorWang, Xianshu
dc.contributor.authorStevens, Kristen
dc.contributor.authorLee, Adam
dc.contributor.authorGiles, Graham G
dc.contributor.authorBaglietto, Laura
dc.contributor.authorSeveri, Gianluca
dc.contributor.authorMcLean, Catriona
dc.contributor.authorAlnæs, Grethe Grenaker
dc.contributor.authorKristensen, Vessela
dc.contributor.authorBørrensen-Dale, Anne-Lise
dc.contributor.authorJohn, Esther M
dc.contributor.authorMiron, Alexander
dc.contributor.authorWinqvist, Robert
dc.contributor.authorPylkäs, Katri
dc.contributor.authorJukkola-Vuorinen, Arja
dc.contributor.authorKauppila, Saila
dc.contributor.authorAndrulis, Irene L
dc.contributor.authorGlendon, Gord
dc.contributor.authorMulligan, Anna Marie
dc.contributor.authorDevilee, Peter
dc.contributor.authorvan Asperen, Christie J
dc.contributor.authorTollenaar, Rob A E M
dc.contributor.authorSeynaeve, Caroline
dc.contributor.authorFigueroa, Jonine D
dc.contributor.authorGarcia-Closas, Montserrat
dc.contributor.authorBrinton, Louise
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorHooning, Maartje J
dc.contributor.authorHollestelle, Antoinette
dc.contributor.authorOldenburg, Rogier A
dc.contributor.authorvan den Ouweland, Ans M W
dc.contributor.authorCox, Angela
dc.contributor.authorReed, Malcolm W R
dc.contributor.authorShah, Mitul
dc.contributor.authorJakubowska, Ania
dc.contributor.authorLubinski, Jan
dc.contributor.authorJaworska, Katarzyna
dc.contributor.authorDurda, Katarzyna
dc.contributor.authorJones, Michael
dc.contributor.authorSchoemaker, Minouk
dc.contributor.authorAshworth, Alan
dc.contributor.authorSwerdlow, Anthony
dc.contributor.authorBeesley, Jonathan
dc.contributor.authorChen, Xiaoqing
dc.contributor.authorMuir, Kenneth R
dc.contributor.authorLophatananon, Artitaya
dc.contributor.authorRattanamongkongul, Suthee
dc.contributor.authorChaiwerawattana, Arkom
dc.contributor.authorKang, Daehee
dc.contributor.authorYoo, Keun-Young
dc.contributor.authorNoh, Dong-Young
dc.contributor.authorShen, Chen-Yang
dc.contributor.authorYu, Jyh-Cherng
dc.contributor.authorWu, Pei-Ei
dc.contributor.authorHsiung, Chia-Ni
dc.contributor.authorPerkins, Annie
dc.contributor.authorSwann, Ruth
dc.contributor.authorVelentzis, Louiza
dc.contributor.authorEccles, Diana M
dc.contributor.authorTapper, Will J
dc.contributor.authorGerty, Susan M
dc.contributor.authorGraham, Nikki J
dc.contributor.authorPonder, Bruce A J
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorPharoah, Paul D P
dc.contributor.authorLathrop, Mark
dc.contributor.authorDunning, Alison M
dc.contributor.authorRahman, Nazneen
dc.contributor.authorPeto, Julian
dc.contributor.authorEaston, Douglas F
dc.date.accessioned2018-09-20T16:09:04Z
dc.date.available2018-09-20T16:09:04Z
dc.date.issued2012-01-22
dc.identifier.citationGhoussaini, Maya; Fletcher, Olivia; Michailidou, Kyriaki; Turnbull, Clare; Schmidt, Marjanka K; Dicks, Ed; Dennis, Joe; Wang, Qin; Humphreys, Manjeet K; Luccarini, Craig; Baynes, Caroline; Conroy, Don; Maranian, Melanie; Ahmed, Shahana; Driver, Kristy; Johnson, Nichola; Orr, Nicholas; dos Santos Silva, Isabel; Waisfisz, Quinten; Meijers-Heijboer, Hanne; Uitterlinden, Andre G; Rivadeneira, Fernando; Hall, Per; Czene, Kamila; Irwanto, Astrid; Liu, Jianjun; Nevanlinna, Heli; Aittomäki, Kristiina; Blomqvist, Carl; Meindl, Alfons; Schmutzler, Rita K; Müller-Myhsok, Bertram; Lichtner, Peter; Chang-Claude, Jenny; Hein, Rebecca; Nickels, Stefan; Flesch-Janys, Dieter; Tsimiklis, Helen; Makalic, Enes; Schmidt, Daniel; Bui, Minh; Hopper, John L; Apicella, Carmel; Park, Daniel J; Southey, Melissa; Hunter, David J; Chanock, Stephen J; Broeks, Annegien; Verhoef, Senno; Hogervorst, Frans B L; Fasching, Peter A; Lux, Michael P; Beckmann, Matthias W; Ekici, Arif B; Sawyer, Elinor; Tomlinson, Ian; Kerin, Michael; Marme, Frederik; Schneeweiss, Andreas; Sohn, Christof; Burwinkel, Barbara; Guénel, Pascal; Truong, Thérèse; Cordina-Duverger, Emilie; Menegaux, Florence; Bojesen, Stig E; Nordestgaard, Børge G; Nielsen, Sune F; Flyger, Henrik; Milne, Roger L; Alonso, M Rosario; González-Neira, Anna; Benítez, Javier; Anton-Culver, Hoda; Ziogas, Argyrios; Bernstein, Leslie; Dur, Christina Clarke; Brenner, Hermann; Müller, Heiko; Arndt, Volker; Stegmaier, Christa; Justenhoven, Christina; Brauch, Hiltrud; Brüning, Thomas; Wang-Gohrke, Shan; Eilber, Ursula; Dörk, Thilo; Schürmann, Peter; Bremer, Michael; Hillemanns, Peter; Bogdanova, Natalia V; Antonenkova, Natalia N; Rogov, Yuri I; Karstens, Johann H; Bermisheva, Marina; Prokofieva, Darya; Khusnutdinova, Elza; Lindblom, Annika; Margolin, Sara; Mannermaa, Arto; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Lambrechts, Diether; Yesilyurt, Betul T; Floris, Giuseppe; Leunen, Karin; Manoukian, Siranoush; Bonanni, Bernardo; Fortuzzi, Stefano; Peterlongo, Paolo; Couch, Fergus J; Wang, Xianshu; Stevens, Kristen; Lee, Adam; Giles, Graham G; Baglietto, Laura; Severi, Gianluca; McLean, Catriona; Alnæs, Grethe Grenaker; Kristensen, Vessela; Børrensen-Dale, Anne-Lise; John, Esther M; Miron, Alexander; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Kauppila, Saila; Andrulis, Irene L; Glendon, Gord; Mulligan, Anna Marie; Devilee, Peter; van Asperen, Christie J; Tollenaar, Rob A E M; Seynaeve, Caroline; Figueroa, Jonine D; Garcia-Closas, Montserrat; Brinton, Louise; Lissowska, Jolanta; Hooning, Maartje J; Hollestelle, Antoinette; Oldenburg, Rogier A; van den Ouweland, Ans M W; Cox, Angela; Reed, Malcolm W R; Shah, Mitul; Jakubowska, Ania; Lubinski, Jan; Jaworska, Katarzyna; Durda, Katarzyna; Jones, Michael; Schoemaker, Minouk; Ashworth, Alan; Swerdlow, Anthony; Beesley, Jonathan; Chen, Xiaoqing; Muir, Kenneth R; Lophatananon, Artitaya; Rattanamongkongul, Suthee; Chaiwerawattana, Arkom; Kang, Daehee; Yoo, Keun-Young; Noh, Dong-Young; Shen, Chen-Yang; Yu, Jyh-Cherng; Wu, Pei-Ei; Hsiung, Chia-Ni; Perkins, Annie; Swann, Ruth; Velentzis, Louiza; Eccles, Diana M; Tapper, Will J; Gerty, Susan M; Graham, Nikki J; Ponder, Bruce A J; Chenevix-Trench, Georgia; Pharoah, Paul D P; Lathrop, Mark; Dunning, Alison M; Rahman, Nazneen; Peto, Julian; Easton, Douglas F (2012). Genome-wide association analysis identifies three new breast cancer susceptibility loci. Nature Genetics 44 (3), 312-U120
dc.identifier.issn1061-4036,1546-1718
dc.identifier.urihttp://hdl.handle.net/10379/11625
dc.description.abstractBreast cancer is the most common cancer among women. To date, 22 common breast cancer susceptibility loci have been identified accounting for similar to 8% of the heritability of the disease. We attempted to replicate 72 promising associations from two independent genome-wide association studies (GWAS) in similar to 70,000 cases and similar to 68,000 controls from 41 case-control studies and 9 breast cancer GWAS. We identified three new breast cancer risk loci at 12p11 (rs10771399; P = 2.7 x 10(-35)), 12q24 (rs1292011; P = 4.3 x 10(-19)) and 21q21 (rs2823093; P = 1.1 x 10(-12)). rs10771399 was associated with similar relative risks for both estrogen receptor (ER)-negative and ER-positive breast cancer, whereas the other two loci were associated only with ER-positive disease. Two of the loci lie in regions that contain strong plausible candidate genes: PTHLH (12p11) has a crucial role in mammary gland development and the establishment of bone metastasis in breast cancer, and NRIP1 (21q21) encodes an ER cofactor and has a role in the regulation of breast cancer cell growth.
dc.publisherSpringer Nature
dc.relation.ispartofNature Genetics
dc.subjecthormone-related protein
dc.subjectdevelopmental regulatory molecule
dc.subjectulnar-mammary syndrome
dc.subjectparathyroid-hormone
dc.subjectnegative-feedback
dc.subjectcommon variants
dc.subjectconfer susceptibility
dc.subjectgene-expression
dc.subjectcell carcinoma
dc.subjectretinoic acid
dc.titleGenome-wide association analysis identifies three new breast cancer susceptibility loci
dc.typeArticle
dc.identifier.doi10.1038/ng.1049
dc.local.publishedsourcehttp://eprints.whiterose.ac.uk/107841/1/Genome-wide%20association%20analysis%20identifies%20three%20new%20breast%20cancer%20susceptibility%20loci.pdf
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