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dc.contributor.authorGrob, Alice
dc.contributor.authorMcStay, Brian
dc.date.accessioned2018-09-20T16:09:44Z
dc.date.available2018-09-20T16:09:44Z
dc.date.issued2014-08-18
dc.identifier.citationGrob, Alice; McStay, Brian (2014). Construction of synthetic nucleoli and what it tells us about propagation of sub-nuclear domains through cell division. Cell Cycle 13 (16), 2501-2508
dc.identifier.issn1538-4101,1551-4005
dc.identifier.urihttp://hdl.handle.net/10379/11738
dc.description.abstractThe cell nucleus is functionally compartmentalized into numerous membraneless and dynamic, yet defined, bodies. The cell cycle inheritance of these nuclear bodies (NBs) is poorly understood at the molecular level. In higher eukaryotes, their propagation is challenged by cell division through an open mitosis, where the nuclear envelope disassembles along with most NBs. A deeper understanding of the mechanisms involved can be achieved using the engineering principles of synthetic biology to construct artificial NBs. Successful biogenesis of such synthetic NBs demonstrates knowledge of the basic mechanisms involved. Application of this approach to the nucleolus, a paradigm of nuclear organization, has highlighted a key role for mitotic bookmarking in the cell cycle propagation of NBs.
dc.publisherInforma UK Limited
dc.relation.ispartofCell Cycle
dc.subjectcell cycle
dc.subjectmitotic bookmarking
dc.subjectnuclear bodies
dc.subjectnucleolus
dc.subjectnucleolar organizer region (nor)
dc.subjectneo-nor
dc.subjectneonucleoli
dc.subjectpseudo-nor
dc.subjectsynthetic biology
dc.subjectubf
dc.subject1 degrees
dc.subjectprimary
dc.subject2 degrees
dc.subjectsecondary
dc.subjectcbs
dc.subjectcajal bodies
dc.subjectcdk
dc.subjectcyclin-dependent kinase
dc.subjectdfc
dc.subjectdense fibrillar component
dc.subjectdj
dc.subjectdistal junction
dc.subjectfcs
dc.subjectfibrillar centers
dc.subjectgc
dc.subjectgranular component
dc.subjecthlbs
dc.subjecthistone locus bodies
dc.subjectigs
dc.subjectintergenic spacers
dc.subjecthmg
dc.subjecthigh mobility group
dc.subjectnbs
dc.subjectnuclear bodies
dc.subjectnors
dc.subjectnucleolar organizer regions
dc.subjectpj
dc.subjectproximal junction
dc.subjectpml
dc.subjectpromyelocytic leukemia
dc.subjectpnbs
dc.subjectpre-nucleolar bodies
dc.subjectpol
dc.subjectrna polymerase
dc.subjectpre-rrna
dc.subjectprecursor rrna
dc.subjectrdna
dc.subjectribosomal genes
dc.subjectrrna
dc.subjectribosomal rna
dc.subjectrnp
dc.subjectribonucleoprotein
dc.subjecttfs
dc.subjecttranscription factors
dc.subjectt-utps
dc.subjecttranscription u 3 proteins
dc.subjectubf
dc.subjectupstream binding factor
dc.subjectxen
dc.subjectxenopus enhancer
dc.subjecti transcription factor
dc.subjectribosomal-rna genes
dc.subjectorganizer regions
dc.subjectmammalian-cells
dc.subjecthigh-mobility
dc.subjectactive genes
dc.subjectfactor hubf
dc.subjectDNA
dc.subjectbody
dc.subjectubf
dc.titleConstruction of synthetic nucleoli and what it tells us about propagation of sub-nuclear domains through cell division
dc.typeArticle
dc.identifier.doi10.4161/15384101.2014.949124
dc.local.publishedsourcehttp://www.tandfonline.com/doi/pdf/10.4161/15384101.2014.949124?needAccess=true
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