Now showing items 1-4 of 4
Influence of stromal–epithelial interactions on breast cancer in vitro and in vivo
Stromal cell-secreted chemokines including CCL2 have been implicated in the primary tumor microenvironment, as mediators of tumor cell migration, proliferation, and angiogenesis. Expression of CCL2 and its principal receptor ...
Relationship between CCL5 and transforming growth factor-β1 (TGFβ1) in breast cancer
Purpose Investigate circulating CCL5 in breast cancer patients and healthy controls, along with gene expression levels in corresponding tumour tissue and isolated primary stromal cells. Hormonal control of CCL5, and a ...
Isolation of secreted microRNAs (miRNAs) from cell-conditioned media
MicroRNAs (miRNAs) have been found to be stable in the circulation of cancer patients raising their potential as circulating biomarkers of disease. The specific source and role, however, of miRNAs in the circulation is ...
Systemic chemokine levels in breast cancer patients and their relationship with circulating menstrual hormones
Introduction The chemokines Stromal Cell-Derived Factor-1 alpha (SDF-1 alpha/CXCL12) and Monocyte Chemotactic Protein-1 (MCP-1/CCL2) have been implicated in breast cancer progression. We recently reported elevated systemic ...