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Relationship between circulating and tissue microRNAs in a murine model of breast cancer.
MiRNAs are key regulators of tumorigenesis that are aberrantly expressed in the circulation and tissue of patients with cancer. The aim of this study was to determine whether miRNA dysregulation in the circulation reflected ...
11q13 is a susceptibility locus for hormone receptor positive breast cancer.
A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these ...
The KRAS-Variant Is Associated with Risk of Developing Double Primary Breast and Ovarian Cancer
Purpose: A germline microRNA binding site-disrupting variant, the KRAS-variant (rs61764370), is associated with an increased risk of developing several cancers. Because this variant is most strongly associated with ovarian ...