Now showing items 1-6 of 6
MicroRNA expression profiling to identify and validate reference genes for relative quantification in colorectal cancer
(Biomed Central, 2010)
Background Advances in high-throughput technologies and bioinformatics have transformed gene expression profiling methodologies. The results of microarray experiments are often validated using reverse transcription ...
Large-scale genotyping identifies 41 new loci associated with breast cancer risk.
(Nature Publishing Group (Macmillan), 2013-03-27)
Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ~9% of the familial risk of the disease. We ...
Relationship between circulating and tissue microRNAs in a murine model of breast cancer.
MiRNAs are key regulators of tumorigenesis that are aberrantly expressed in the circulation and tissue of patients with cancer. The aim of this study was to determine whether miRNA dysregulation in the circulation reflected ...
Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer.
(Nature Publishing Group (Macmillan), 2013-04)
TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers. Using the Illumina custom genotyping array iCOGs, we analyzed ~480 SNPs at the TERT locus in breast (n = 103,991), ...
11q13 is a susceptibility locus for hormone receptor positive breast cancer.
A recent two-stage genome-wide association study (GWAS) identified five novel breast cancer susceptibility loci on chromosomes 9, 10, and 11. To provide more reliable estimates of the relative risk associated with these ...
The KRAS-Variant Is Associated with Risk of Developing Double Primary Breast and Ovarian Cancer
Purpose: A germline microRNA binding site-disrupting variant, the KRAS-variant (rs61764370), is associated with an increased risk of developing several cancers. Because this variant is most strongly associated with ovarian ...