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dc.contributor.authorKyne, Ciara
dc.contributor.authorCrowley, Peter B.
dc.date.accessioned2018-09-20T16:13:45Z
dc.date.available2018-09-20T16:13:45Z
dc.date.issued2016-05-11
dc.identifier.citationKyne, Ciara; Crowley, Peter B. (2016). Grasping the nature of the cell interior: fromphysiological chemistrytochemical biology. The FEBS Journal 283 (16), 3016-3028
dc.identifier.issn1742-464X
dc.identifier.urihttp://hdl.handle.net/10379/12343
dc.description.abstractCurrent models of the cell interior emphasise its crowded, chemically complex and dynamically organised structure. Although the chemical composition of cells is known, the cooperative intermolecular interactions that govern cell ultrastructure are poorly understood. A major goal of biochemistry is to capture these myriad interactions in vivo. We consider the landmark discoveries that have shaped this objective, starting from the vitalist framework established by early natural philosophers. Through this historical revisionism, we extract important lessons for the bioinspired chemists of today. Scientific specialisation tends to insulate seminal ideas and hamper the unification of paradigms across biology. Therefore, we call for interdisciplinary collaboration in grappling with the complex cell interior. Recent successes in integrative structural biology and chemical biology demonstrate the power of hybrid approaches. The future roles of the (bio)chemist and model systems are also discussed as starting points for in vivo explorations.
dc.publisherWiley-Blackwell
dc.relation.ispartofThe FEBS Journal
dc.subjectcytoplasmic structure
dc.subjectemergent physicochemical properties
dc.subjecthybrid methods
dc.subjectin vivo studies
dc.subjectmacromolecular machines
dc.subjectprotein-protein interactions
dc.subjectmagnetic-resonance-spectroscopy
dc.subjectescherichia-coli
dc.subjectquinary structure
dc.subjectnmr-spectroscopy
dc.subjectliving cells
dc.subjectmacromolecular interactions
dc.subjectcryoelectron tomography
dc.subjectstructural biology
dc.subjectphase-separation
dc.titleGrasping the nature of the cell interior: fromphysiological chemistrytochemical biology
dc.typeArticle
dc.identifier.doi10.1111/febs.13744
dc.local.publishedsourcehttp://onlinelibrary.wiley.com/doi/10.1111/febs.13744/pdf
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