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dc.contributor.authorPettenuzzo, Andrea
dc.contributor.authorPigot, Rebecca
dc.contributor.authorRonconi, Luca
dc.date.accessioned2018-09-20T16:21:31Z
dc.date.available2018-09-20T16:21:31Z
dc.date.issued2017-01-23
dc.identifier.citationPettenuzzo, Andrea; Pigot, Rebecca; Ronconi, Luca (2017). Vitamin b12-metal conjugates for targeted chemotherapy and diagnosis: current status and future prospects. European Journal of Inorganic Chemistry (12), 1625-1638
dc.identifier.issn1434-1948
dc.identifier.urihttp://hdl.handle.net/10379/13462
dc.description.abstractVitamin B-12 (cyanocobalamin) is a vital nutrient characterized by very low bioavailability. Owing to their extremely high proliferation rates, tumor cells show increased demand for nutrients in comparison with healthy ones, including the greater uptake of vitamin B-12. This avidity for cyanocobalamin can thus be exploited for the site-specific delivery of drugs directly into tumor cells by conjugation of vitamin B-12 (carrier) to either chemotherapeutic or diagnostic agents. In particular, tailored cobalamin-containing substrates can be conjugated to metal-based drugs to achieve targeted delivery into the affected tissues, thus accomplishing biomolecular recognition and tumor selectivity. Progress in the development of metalvitamin B-12 conjugates for medicinal applications is summarized and discussed.
dc.publisherWiley-Blackwell
dc.relation.ispartofEuropean Journal of Inorganic Chemistry
dc.subjectvitamin b-12
dc.subjectcobalamin
dc.subjectmetallodrugs
dc.subjectdrug design
dc.subjectmedicinal inorganic chemistry targeted chemotherapy
dc.subjecttumor imaging
dc.subjectantitumor agents
dc.subjectimaging agents
dc.subjecttransition-metal-complexes
dc.subjecttranscobalamin ii receptor
dc.subjectco-releasing molecules
dc.subjecttype-1 diabetic mice
dc.subjectmri contrast agents
dc.subjectcarbon-monoxide
dc.subjectmedicinal applications
dc.subjectlabeled vitamin-b12
dc.subjectcobalamin analogs
dc.subjectb-12 trafficking
dc.titleVitamin b12-metal conjugates for targeted chemotherapy and diagnosis: current status and future prospects
dc.typeArticle
dc.identifier.doi10.1002/ejic.201601217
dc.local.publishedsourcehttp://onlinelibrary.wiley.com/doi/10.1002/ejic.201601217/pdf
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