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dc.contributor.authorPirie, Ailith
dc.contributor.author,
dc.contributor.authorGuo, Qi
dc.contributor.authorKraft, Peter
dc.contributor.authorCanisius, Sander
dc.contributor.authorEccles, Diana M
dc.contributor.authorRahman, Nazneen
dc.contributor.authorNevanlinna, Heli
dc.contributor.authorChen, Constance
dc.contributor.authorKhan, Sofia
dc.contributor.authorTyrer, Jonathan
dc.contributor.authorBolla, Manjeet K
dc.contributor.authorWang, Qin
dc.contributor.authorDennis, Joe
dc.contributor.authorMichailidou, Kyriaki
dc.contributor.authorLush, Michael
dc.contributor.authorDunning, Alison M
dc.contributor.authorShah, Mitul
dc.contributor.authorCzene, Kamila
dc.contributor.authorDarabi, Hatef
dc.contributor.authorEriksson, Mikael
dc.contributor.authorLambrechts, Dieter
dc.contributor.authorWeltens, Caroline
dc.contributor.authorLeunen, Karin
dc.contributor.authorvan Ongeval, Chantal
dc.contributor.authorNordestgaard, Børge G
dc.contributor.authorNielsen, Sune F
dc.contributor.authorFlyger, Henrik
dc.contributor.authorRudolph, Anja
dc.contributor.authorSeibold, Petra
dc.contributor.authorFlesch-Janys, Dieter
dc.contributor.authorBlomqvist, Carl
dc.contributor.authorAittomäki, Kristiina
dc.contributor.authorFagerholm, Rainer
dc.contributor.authorMuranen, Taru A
dc.contributor.authorOlsen, Janet E
dc.contributor.authorHallberg, Emily
dc.contributor.authorVachon, Celine
dc.contributor.authorKnight, Julia A
dc.contributor.authorGlendon, Gord
dc.contributor.authorMulligan, Anna Marie
dc.contributor.authorBroeks, Annegien
dc.contributor.authorCornelissen, Sten
dc.contributor.authorHaiman, Christopher A
dc.contributor.authorHenderson, Brian E
dc.contributor.authorSchumacher, Frederick
dc.contributor.authorLe Marchand, Loic
dc.contributor.authorHopper, John L
dc.contributor.authorTsimiklis, Helen
dc.contributor.authorApicella, Carmel
dc.contributor.authorSouthey, Melissa C
dc.contributor.authorCross, Simon S
dc.contributor.authorReed, Malcolm WR
dc.contributor.authorGiles, Graham G
dc.contributor.authorMilne, Roger L
dc.contributor.authorMcLean, Catriona
dc.contributor.authorWinqvist, Robert
dc.contributor.authorPylkäs, Katri
dc.contributor.authorJukkola-Vuorinen, Arja
dc.contributor.authorGrip, Mervi
dc.contributor.authorHooning, Maartje J
dc.contributor.authorHollestelle, Antoinette
dc.contributor.authorMartens, John WM
dc.contributor.authorvan den Ouweland, Ans MW
dc.contributor.authorMarme, Federick
dc.contributor.authorSchneeweiss, Andreas
dc.contributor.authorYang, Rongxi
dc.contributor.authorBurwinkel, Barbara
dc.contributor.authorFigueroa, Jonine
dc.contributor.authorChanock, Stephen J
dc.contributor.authorLissowska, Jolanta
dc.contributor.authorSawyer, Elinor J
dc.contributor.authorTomlinson, Ian
dc.contributor.authorKerin, Michael J
dc.contributor.authorMiller, Nicola
dc.contributor.authorBrenner, Hermann
dc.contributor.authorButterbach, Katja
dc.contributor.authorHolleczek, Bernd
dc.contributor.authorKataja, Vesa
dc.contributor.authorKosma, Veli-Matti
dc.contributor.authorHartikainen, Jaana M
dc.contributor.authorLi, Jingmei
dc.contributor.authorBrand, Judith S
dc.contributor.authorHumphreys, Keith
dc.contributor.authorDevilee, Peter
dc.contributor.authorTollenaar, Robert AEM
dc.contributor.authorSeynaeve, Caroline
dc.contributor.authorRadice, Paolo
dc.contributor.authorPeterlongo, Paolo
dc.contributor.authorManoukian, Siranoush
dc.contributor.authorFicarazzi, Filomena
dc.contributor.authorBeckmann, Matthias W
dc.contributor.authorHein, Alexander
dc.contributor.authorEkici, Arif B
dc.contributor.authorBalleine, Rosemary
dc.contributor.authorPhillips, Kelly-Anne
dc.contributor.authorBenitez, Javier
dc.contributor.authorZamora, M Pilar
dc.contributor.authorPerez, Jose Ignacio Arias
dc.contributor.authorMenéndez, Primitiva
dc.contributor.authorJakubowska, Anna
dc.contributor.authorLubinski, Jan
dc.contributor.authorGronwald, Jacek
dc.contributor.authorDurda, Katarzyna
dc.contributor.authorHamann, Ute
dc.contributor.authorKabisch, Maria
dc.contributor.authorUlmer, Hans Ulrich
dc.contributor.authorRüdiger, Thomas
dc.contributor.authorMargolin, Sara
dc.contributor.authorKristensen, Vessela
dc.contributor.authorNord, Siljie
dc.contributor.authorEvans, D Gareth
dc.contributor.authorAbraham, Jean
dc.contributor.authorEarl, Helena
dc.contributor.authorPoole, Christopher J
dc.contributor.authorHiller, Louise
dc.contributor.authorDunn, Janet A
dc.contributor.authorBowden, Sarah
dc.contributor.authorYang, Rose
dc.contributor.authorCampa, Daniele
dc.contributor.authorDiver, W Ryan
dc.contributor.authorGapstur, Susan M
dc.contributor.authorGaudet, Mia M
dc.contributor.authorHankinson, Susan
dc.contributor.authorHoover, Robert N
dc.contributor.authorHüsing, Anika
dc.contributor.authorKaaks, Rudolf
dc.contributor.authorMachiela, Mitchell J
dc.contributor.authorWillett, Walter
dc.contributor.authorBarrdahl, Myrto
dc.contributor.authorCanzian, Federico
dc.contributor.authorChin, Suet-Feung
dc.contributor.authorCaldas, Carlos
dc.contributor.authorHunter, David J
dc.contributor.authorLindstrom, Sara
dc.contributor.authorGarcia-Closas, Montserrat
dc.contributor.authorCouch, Fergus J
dc.contributor.authorChenevix-Trench, Georgia
dc.contributor.authorMannermaa, Arto
dc.contributor.authorAndrulis, Irene L
dc.contributor.authorHall, Per
dc.contributor.authorChang-Claude, Jenny
dc.contributor.authorEaston, Douglas F
dc.contributor.authorBojesen, Stig E
dc.contributor.authorCox, Angela
dc.contributor.authorFasching, Peter A
dc.contributor.authorPharoah, Paul DP
dc.contributor.authorSchmidt, Marjanka K
dc.contributor.author,
dc.date.accessioned2018-09-20T16:21:42Z
dc.date.available2018-09-20T16:21:42Z
dc.date.issued2015-04-22
dc.identifier.citationPirie, Ailith; , ; Guo, Qi; Kraft, Peter; Canisius, Sander; Eccles, Diana M; Rahman, Nazneen; Nevanlinna, Heli; Chen, Constance; Khan, Sofia; Tyrer, Jonathan; Bolla, Manjeet K; Wang, Qin; Dennis, Joe; Michailidou, Kyriaki; Lush, Michael; Dunning, Alison M; Shah, Mitul; Czene, Kamila; Darabi, Hatef; Eriksson, Mikael; Lambrechts, Dieter; Weltens, Caroline; Leunen, Karin; van Ongeval, Chantal; Nordestgaard, Børge G; Nielsen, Sune F; Flyger, Henrik; Rudolph, Anja; Seibold, Petra; Flesch-Janys, Dieter; Blomqvist, Carl; Aittomäki, Kristiina; Fagerholm, Rainer; Muranen, Taru A; Olsen, Janet E; Hallberg, Emily; Vachon, Celine; Knight, Julia A; Glendon, Gord; Mulligan, Anna Marie; Broeks, Annegien; Cornelissen, Sten; Haiman, Christopher A; Henderson, Brian E; Schumacher, Frederick; Le Marchand, Loic; Hopper, John L; Tsimiklis, Helen; Apicella, Carmel; Southey, Melissa C; Cross, Simon S; Reed, Malcolm WR; Giles, Graham G; Milne, Roger L; McLean, Catriona; Winqvist, Robert; Pylkäs, Katri; Jukkola-Vuorinen, Arja; Grip, Mervi; Hooning, Maartje J; Hollestelle, Antoinette; Martens, John WM; van den Ouweland, Ans MW; Marme, Federick; Schneeweiss, Andreas; Yang, Rongxi; Burwinkel, Barbara; Figueroa, Jonine; Chanock, Stephen J; Lissowska, Jolanta; Sawyer, Elinor J; Tomlinson, Ian; Kerin, Michael J; Miller, Nicola; Brenner, Hermann; Butterbach, Katja; Holleczek, Bernd; Kataja, Vesa; Kosma, Veli-Matti; Hartikainen, Jaana M; Li, Jingmei; Brand, Judith S; Humphreys, Keith; Devilee, Peter; Tollenaar, Robert AEM; Seynaeve, Caroline; Radice, Paolo; Peterlongo, Paolo; Manoukian, Siranoush; Ficarazzi, Filomena; Beckmann, Matthias W; Hein, Alexander; Ekici, Arif B; Balleine, Rosemary; Phillips, Kelly-Anne; Benitez, Javier; Zamora, M Pilar; Perez, Jose Ignacio Arias; Menéndez, Primitiva; Jakubowska, Anna; Lubinski, Jan; Gronwald, Jacek; Durda, Katarzyna; Hamann, Ute; Kabisch, Maria; Ulmer, Hans Ulrich; Rüdiger, Thomas; Margolin, Sara; Kristensen, Vessela; Nord, Siljie; Evans, D Gareth; Abraham, Jean; Earl, Helena; Poole, Christopher J; Hiller, Louise; Dunn, Janet A; Bowden, Sarah; Yang, Rose; Campa, Daniele; Diver, W Ryan; Gapstur, Susan M; Gaudet, Mia M; Hankinson, Susan; Hoover, Robert N; Hüsing, Anika; Kaaks, Rudolf; Machiela, Mitchell J; Willett, Walter; Barrdahl, Myrto; Canzian, Federico; Chin, Suet-Feung; Caldas, Carlos; Hunter, David J; Lindstrom, Sara; Garcia-Closas, Montserrat; Couch, Fergus J; Chenevix-Trench, Georgia; Mannermaa, Arto; Andrulis, Irene L; Hall, Per; Chang-Claude, Jenny; Easton, Douglas F; Bojesen, Stig E; Cox, Angela; Fasching, Peter A; Pharoah, Paul DP; Schmidt, Marjanka K; , (2015). Common germline polymorphisms associated with breast cancer-specific survival. Breast Cancer Research 17 ,
dc.identifier.issn1465-542X
dc.identifier.urihttp://hdl.handle.net/10379/13489
dc.description.abstractIntroduction: Previous studies have identified common germline variants nominally associated with breast cancer survival. These associations have not been widely replicated in further studies. The purpose of this study was to evaluate the association of previously reported SNPs with breast cancer-specific survival using data from a pooled analysis of eight breast cancer survival genome-wide association studies (GWAS) from the Breast Cancer Association Consortium. Methods: A literature review was conducted of all previously published associations between common germline variants and three survival outcomes: breast cancer-specific survival, overall survival and disease-free survival. All associations that reached the nominal significance level of P value <0.05 were included. Single nucleotide polymorphisms that had been previously reported as nominally associated with at least one survival outcome were evaluated in the pooled analysis of over 37,000 breast cancer cases for association with breast cancer-specific survival. Previous associations were evaluated using a one-sided test based on the reported direction of effect. Results: Fifty-six variants from 45 previous publications were evaluated in the meta-analysis. Fifty-four of these were evaluated in the full set of 37,954 breast cancer cases with 2,900 events and the two additional variants were evaluated in a reduced sample size of 30,000 samples in order to ensure independence from the previously published studies. Five variants reached nominal significance (P <0.05) in the pooled GWAS data compared to 2.8 expected under the null hypothesis. Seven additional variants were associated (P <0.05) with ER-positive disease. Conclusions: Although no variants reached genome-wide significance (P <5 x 10(-8)), these results suggest that there is some evidence of association between candidate common germline variants and breast cancer prognosis. Larger studies from multinational collaborations are necessary to increase the power to detect associations, between common variants and prognosis, at more stringent significance levels.
dc.publisherSpringer Nature
dc.relation.ispartofBreast Cancer Research
dc.subjectsingle-nucleotide polymorphisms
dc.subjectgenome-wide association
dc.subjectthan-t polymorphism
dc.subjectgenetic polymorphisms
dc.subjectadjuvant therapy
dc.subjectrisk
dc.subjectprognosis
dc.subjectoutcomes
dc.subjectvariants
dc.subjectgenotype
dc.titleCommon germline polymorphisms associated with breast cancer-specific survival
dc.typeArticle
dc.identifier.doi10.1186/s13058-015-0570-7
dc.local.publishedsourcehttps://breast-cancer-research.biomedcentral.com/track/pdf/10.1186/s13058-015-0570-7?site=breast-cancer-research.biomedcentral.com
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