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dc.contributor.authorStein, Jason L
dc.contributor.authorMedland, Sarah E
dc.contributor.authorVasquez, Alejandro Arias
dc.contributor.authorHibar, Derrek P
dc.contributor.authorSenstad, Rudy E
dc.contributor.authorWinkler, Anderson M
dc.contributor.authorToro, Roberto
dc.contributor.authorAppel, Katja
dc.contributor.authorBartecek, Richard
dc.contributor.authorBergmann, Ørjan
dc.contributor.authorBernard, Manon
dc.contributor.authorBrown, Andrew A
dc.contributor.authorCannon, Dara M
dc.contributor.authorChakravarty, M Mallar
dc.contributor.authorChristoforou, Andrea
dc.contributor.authorDomin, Martin
dc.contributor.authorGrimm, Oliver
dc.contributor.authorHollinshead, Marisa
dc.contributor.authorHolmes, Avram J
dc.contributor.authorHomuth, Georg
dc.contributor.authorHottenga, Jouke-Jan
dc.contributor.authorLangan, Camilla
dc.contributor.authorLopez, Lorna M
dc.contributor.authorHansell, Narelle K
dc.contributor.authorHwang, Kristy S
dc.contributor.authorKim, Sungeun
dc.contributor.authorLaje, Gonzalo
dc.contributor.authorLee, Phil H
dc.contributor.authorLiu, Xinmin
dc.contributor.authorLoth, Eva
dc.contributor.authorLourdusamy, Anbarasu
dc.contributor.authorMattingsdal, Morten
dc.contributor.authorMohnke, Sebastian
dc.contributor.authorManiega, Susana Muñoz
dc.contributor.authorNho, Kwangsik
dc.contributor.authorNugent, Allison C
dc.contributor.authorO'Brien, Carol
dc.contributor.authorPapmeyer, Martina
dc.contributor.authorPütz, Benno
dc.contributor.authorRamasamy, Adaikalavan
dc.contributor.authorRasmussen, Jerod
dc.contributor.authorRijpkema, Mark
dc.contributor.authorRisacher, Shannon L
dc.contributor.authorRoddey, J Cooper
dc.contributor.authorRose, Emma J
dc.contributor.authorRyten, Mina
dc.contributor.authorShen, Li
dc.contributor.authorSprooten, Emma
dc.contributor.authorStrengman, Eric
dc.contributor.authorTeumer, Alexander
dc.contributor.authorTrabzuni, Daniah
dc.contributor.authorTurner, Jessica
dc.contributor.authorvan Eijk, Kristel
dc.contributor.authorvan Erp, Theo G M
dc.contributor.authorvan Tol, Marie-Jose
dc.contributor.authorWittfeld, Katharina
dc.contributor.authorWolf, Christiane
dc.contributor.authorWoudstra, Saskia
dc.contributor.authorAleman, Andre
dc.contributor.authorAlhusaini, Saud
dc.contributor.authorAlmasy, Laura
dc.contributor.authorBinder, Elisabeth B
dc.contributor.authorBrohawn, David G
dc.contributor.authorCantor, Rita M
dc.contributor.authorCarless, Melanie A
dc.contributor.authorCorvin, Aiden
dc.contributor.authorCzisch, Michael
dc.contributor.authorCurran, Joanne E
dc.contributor.authorDavies, Gail
dc.contributor.authorde Almeida, Marcio A A
dc.contributor.authorDelanty, Norman
dc.contributor.authorDepondt, Chantal
dc.contributor.authorDuggirala, Ravi
dc.contributor.authorDyer, Thomas D
dc.contributor.authorErk, Susanne
dc.contributor.authorFagerness, Jesen
dc.contributor.authorFox, Peter T
dc.contributor.authorFreimer, Nelson B
dc.contributor.authorGill, Michael
dc.contributor.authorGöring, Harald H H
dc.contributor.authorHagler, Donald J
dc.contributor.authorHoehn, David
dc.contributor.authorHolsboer, Florian
dc.contributor.authorHoogman, Martine
dc.contributor.authorHosten, Norbert
dc.contributor.authorJahanshad, Neda
dc.contributor.authorJohnson, Matthew P
dc.contributor.authorKasperaviciute, Dalia
dc.contributor.authorKent, Jack W
dc.contributor.authorKochunov, Peter
dc.contributor.authorLancaster, Jack L
dc.contributor.authorLawrie, Stephen M
dc.contributor.authorLiewald, David C
dc.contributor.authorMandl, René
dc.contributor.authorMatarin, Mar
dc.contributor.authorMattheisen, Manuel
dc.contributor.authorMeisenzahl, Eva
dc.contributor.authorMelle, Ingrid
dc.contributor.authorMoses, Eric K
dc.contributor.authorMühleisen, Thomas W
dc.contributor.authorNauck, Matthias
dc.contributor.authorNöthen, Markus M
dc.contributor.authorOlvera, Rene L
dc.contributor.authorPandolfo, Massimo
dc.contributor.authorPike, G Bruce
dc.contributor.authorPuls, Ralf
dc.contributor.authorReinvang, Ivar
dc.contributor.authorRentería, Miguel E
dc.contributor.authorRietschel, Marcella
dc.contributor.authorRoffman, Joshua L
dc.contributor.authorRoyle, Natalie A
dc.contributor.authorRujescu, Dan
dc.contributor.authorSavitz, Jonathan
dc.contributor.authorSchnack, Hugo G
dc.contributor.authorSchnell, Knut
dc.contributor.authorSeiferth, Nina
dc.contributor.authorSmith, Colin
dc.contributor.authorSteen, Vidar M
dc.contributor.authorValdés Hernández, Maria C
dc.contributor.authorVan den Heuvel, Martijn
dc.contributor.authorvan der Wee, Nic J
dc.contributor.authorVan Haren, Neeltje E M
dc.contributor.authorVeltman, Joris A
dc.contributor.authorVölzke, Henry
dc.contributor.authorWalker, Robert
dc.contributor.authorWestlye, Lars T
dc.contributor.authorWhelan, Christopher D
dc.contributor.authorAgartz, Ingrid
dc.contributor.authorBoomsma, Dorret I
dc.contributor.authorCavalleri, Gianpiero L
dc.contributor.authorDale, Anders M
dc.contributor.authorDjurovic, Srdjan
dc.contributor.authorDrevets, Wayne C
dc.contributor.authorHagoort, Peter
dc.contributor.authorHall, Jeremy
dc.contributor.authorHeinz, Andreas
dc.contributor.authorJack, Clifford R
dc.contributor.authorForoud, Tatiana M
dc.contributor.authorLe Hellard, Stephanie
dc.contributor.authorMacciardi, Fabio
dc.contributor.authorMontgomery, Grant W
dc.contributor.authorPoline, Jean Baptiste
dc.contributor.authorPorteous, David J
dc.contributor.authorSisodiya, Sanjay M
dc.contributor.authorStarr, John M
dc.contributor.authorSussmann, Jessika
dc.contributor.authorToga, Arthur W
dc.contributor.authorVeltman, Dick J
dc.contributor.authorWalter, Henrik
dc.contributor.authorWeiner, Michael W
dc.contributor.authorBis, Joshua C
dc.contributor.authorIkram, M Arfan
dc.contributor.authorSmith, Albert V
dc.contributor.authorGudnason, Vilmundur
dc.contributor.authorTzourio, Christophe
dc.contributor.authorVernooij, Meike W
dc.contributor.authorLauner, Lenore J
dc.contributor.authorDeCarli, Charles
dc.contributor.authorSeshadri, Sudha
dc.contributor.authorAndreassen, Ole A
dc.contributor.authorApostolova, Liana G
dc.contributor.authorBastin, Mark E
dc.contributor.authorBlangero, John
dc.contributor.authorBrunner, Han G
dc.contributor.authorBuckner, Randy L
dc.contributor.authorCichon, Sven
dc.contributor.authorCoppola, Giovanni
dc.contributor.authorde Zubicaray, Greig I
dc.contributor.authorDeary, Ian J
dc.contributor.authorDonohoe, Gary
dc.contributor.authorde Geus, Eco J C
dc.contributor.authorEspeseth, Thomas
dc.contributor.authorFernández, Guillén
dc.contributor.authorGlahn, David C
dc.contributor.authorGrabe, Hans J
dc.contributor.authorHardy, John
dc.contributor.authorHulshoff Pol, Hilleke E
dc.contributor.authorJenkinson, Mark
dc.contributor.authorKahn, René S
dc.contributor.authorMcDonald, Colm
dc.contributor.authorMcIntosh, Andrew M
dc.contributor.authorMcMahon, Francis J
dc.contributor.authorMcMahon, Katie L
dc.contributor.authorMeyer-Lindenberg, Andreas
dc.contributor.authorMorris, Derek W
dc.contributor.authorMüller-Myhsok, Bertram
dc.contributor.authorNichols, Thomas E
dc.contributor.authorOphoff, Roel A
dc.contributor.authorPaus, Tomas
dc.contributor.authorPausova, Zdenka
dc.contributor.authorPenninx, Brenda W
dc.contributor.authorPotkin, Steven G
dc.contributor.authorSämann, Philipp G
dc.contributor.authorSaykin, Andrew J
dc.contributor.authorSchumann, Gunter
dc.contributor.authorSmoller, Jordan W
dc.contributor.authorWardlaw, Joanna M
dc.contributor.authorWeale, Michael E
dc.contributor.authorMartin, Nicholas G
dc.contributor.authorFranke, Barbara
dc.contributor.authorWright, Margaret J
dc.contributor.authorThompson, Paul M
dc.date.accessioned2018-09-20T16:25:29Z
dc.date.available2018-09-20T16:25:29Z
dc.date.issued2012-04-15
dc.identifier.citationStein, Jason L; Medland, Sarah E; Vasquez, Alejandro Arias; Hibar, Derrek P; Senstad, Rudy E; Winkler, Anderson M; Toro, Roberto; Appel, Katja; Bartecek, Richard; Bergmann, Ørjan; Bernard, Manon; Brown, Andrew A; Cannon, Dara M; Chakravarty, M Mallar; Christoforou, Andrea; Domin, Martin; Grimm, Oliver; Hollinshead, Marisa; Holmes, Avram J; Homuth, Georg; Hottenga, Jouke-Jan; Langan, Camilla; Lopez, Lorna M; Hansell, Narelle K; Hwang, Kristy S; Kim, Sungeun; Laje, Gonzalo; Lee, Phil H; Liu, Xinmin; Loth, Eva; Lourdusamy, Anbarasu; Mattingsdal, Morten; Mohnke, Sebastian; Maniega, Susana Muñoz; Nho, Kwangsik; Nugent, Allison C; O'Brien, Carol; Papmeyer, Martina; Pütz, Benno; Ramasamy, Adaikalavan; Rasmussen, Jerod; Rijpkema, Mark; Risacher, Shannon L; Roddey, J Cooper; Rose, Emma J; Ryten, Mina; Shen, Li; Sprooten, Emma; Strengman, Eric; Teumer, Alexander; Trabzuni, Daniah; Turner, Jessica; van Eijk, Kristel; van Erp, Theo G M; van Tol, Marie-Jose; Wittfeld, Katharina; Wolf, Christiane; Woudstra, Saskia; Aleman, Andre; Alhusaini, Saud; Almasy, Laura; Binder, Elisabeth B; Brohawn, David G; Cantor, Rita M; Carless, Melanie A; Corvin, Aiden; Czisch, Michael; Curran, Joanne E; Davies, Gail; de Almeida, Marcio A A; Delanty, Norman; Depondt, Chantal; Duggirala, Ravi; Dyer, Thomas D; Erk, Susanne; Fagerness, Jesen; Fox, Peter T; Freimer, Nelson B; Gill, Michael; Göring, Harald H H; Hagler, Donald J; Hoehn, David; Holsboer, Florian; Hoogman, Martine; Hosten, Norbert; Jahanshad, Neda; Johnson, Matthew P; Kasperaviciute, Dalia; Kent, Jack W; Kochunov, Peter; Lancaster, Jack L; Lawrie, Stephen M; Liewald, David C; Mandl, René; Matarin, Mar; Mattheisen, Manuel; Meisenzahl, Eva; Melle, Ingrid; Moses, Eric K; Mühleisen, Thomas W; Nauck, Matthias; Nöthen, Markus M; Olvera, Rene L; Pandolfo, Massimo; Pike, G Bruce; Puls, Ralf; Reinvang, Ivar; Rentería, Miguel E; Rietschel, Marcella; Roffman, Joshua L; Royle, Natalie A; Rujescu, Dan; Savitz, Jonathan; Schnack, Hugo G; Schnell, Knut; Seiferth, Nina; Smith, Colin; Steen, Vidar M; Valdés Hernández, Maria C; Van den Heuvel, Martijn; van der Wee, Nic J; Van Haren, Neeltje E M; Veltman, Joris A; Völzke, Henry; Walker, Robert; Westlye, Lars T; Whelan, Christopher D; Agartz, Ingrid; Boomsma, Dorret I; Cavalleri, Gianpiero L; Dale, Anders M; Djurovic, Srdjan; Drevets, Wayne C; Hagoort, Peter; Hall, Jeremy; Heinz, Andreas; Jack, Clifford R; Foroud, Tatiana M; Le Hellard, Stephanie; Macciardi, Fabio; Montgomery, Grant W; Poline, Jean Baptiste; Porteous, David J; Sisodiya, Sanjay M; Starr, John M; Sussmann, Jessika; Toga, Arthur W; Veltman, Dick J; Walter, Henrik; Weiner, Michael W; Bis, Joshua C; Ikram, M Arfan; Smith, Albert V; Gudnason, Vilmundur; Tzourio, Christophe; Vernooij, Meike W; Launer, Lenore J; DeCarli, Charles; Seshadri, Sudha; Andreassen, Ole A; Apostolova, Liana G; Bastin, Mark E; Blangero, John; Brunner, Han G; Buckner, Randy L; Cichon, Sven; Coppola, Giovanni; de Zubicaray, Greig I; Deary, Ian J; Donohoe, Gary; de Geus, Eco J C; Espeseth, Thomas; Fernández, Guillén; Glahn, David C; Grabe, Hans J; Hardy, John; Hulshoff Pol, Hilleke E; Jenkinson, Mark; Kahn, René S; McDonald, Colm; McIntosh, Andrew M; McMahon, Francis J; McMahon, Katie L; Meyer-Lindenberg, Andreas; Morris, Derek W; Müller-Myhsok, Bertram; Nichols, Thomas E; Ophoff, Roel A; Paus, Tomas; Pausova, Zdenka; Penninx, Brenda W; Potkin, Steven G; Sämann, Philipp G; Saykin, Andrew J; Schumann, Gunter; Smoller, Jordan W; Wardlaw, Joanna M; Weale, Michael E; Martin, Nicholas G; Franke, Barbara; Wright, Margaret J; Thompson, Paul M (2012). Identification of common variants associated with human hippocampal and intracranial volumes. Nature Genetics 44 (5),
dc.identifier.issn1061-4036,1546-1718
dc.identifier.urihttp://hdl.handle.net/10379/14009
dc.description.abstractIdentifying genetic variants influencing human brain structures may reveal new biological mechanisms underlying cognition and neuropsychiatric illness. The volume of the hippocampus is a biomarker of incipient Alzheimer's disease(1,2) and is reduced in schizophrenia(3), major depression(4) and mesial temporal lobe epilepsy(5). Whereas many brain imaging phenotypes are highly heritable(6,7), identifying and replicating genetic influences has been difficult, as small effects and the high costs of magnetic resonance imaging (MRI) have led to underpowered studies. Here we report genome-wide association meta-analyses and replication for mean bilateral hippocampal, total brain and intracranial volumes from a large multinational consortium. The intergenic variant rs7294919 was associated with hippocampal volume (12q24.22; N = 21,151; P = 6.70 x 10(-16)) and the expression levels of the positional candidate gene TESC in brain tissue. Additionally, rs10784502, located within HMGA2, was associated with intracranial volume (12q14.3; N = 15,782; P = 1.12 x 10(-12)). We also identified a suggestive association with total brain volume at rs10494373 within DDR2 (1q23.3; N = 6,500; P = 5.81 x 10(-7)).
dc.publisherSpringer Nature
dc.relation.ispartofNature Genetics
dc.subjectgenome-wide association
dc.subjecttemporal-lobe epilepsy
dc.subjectautomated segmentation
dc.subjectgenotype imputation
dc.subjectalzheimers-disease
dc.subjectbrain volume
dc.subjecthuman height
dc.subjectfunctional implications
dc.subjectna+/h+ exchanger
dc.subjectunified approach
dc.titleIdentification of common variants associated with human hippocampal and intracranial volumes
dc.typeArticle
dc.identifier.doi10.1038/ng.2250
dc.local.publishedsourcehttp://www.tara.tcd.ie/bitstream/2262/69354/1/nihms378125.pdf
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