Show simple item record

dc.contributor.authorMadasu, M.K.
dc.contributor.authorRoche, Michelle
dc.contributor.authorFinn, David P.
dc.identifier.citationMadasu, M.K., Roche, Michelle, & Finn, David P. (2015). Supraspinal Transient Receptor Potential Subfamily V Member 1 (TRPV1) in Pain and Psychiatric Disorders. In David P. Finn & Brian E. Leonard (Eds.), Pain in Psychiatric Disorders: Modern Trends Pharmacopsychiatry (Vol. 30, pp. 80-93). Basel: Karger.en_IE
dc.description.abstractThe transient receptor potential subfamily V member 1 (TRPV1) belongs to the diverse transient receptor potential (TRP) family of cation channels. It was first characterized in primary afferent fibres as a receptor for capsaicin. Peripheral TRPV1 has a very well-described role in nociception. However, TRPV1 is now recognized to have a broader distribution and function, with supraspinal/brain TRPV1 known to modulate pain processing. Recently, studies employing histological, genetic and pharmacological approaches have provided evidence that supraspinal TRPV1 also modulates brain neurobiology and behaviours related to anxiety, depression and schizophrenia. Key brain regions involved in TRPV1-mediated modulation of pain and affect include the periaqueductal grey, hippocampus and medial prefrontal cortex. Thus, TRPV1 in the brain is emerging as an important molecular substrate which is dually implicated in both pain and psychiatric disorders, and represents a novel therapeutic target for these conditions and their comorbidity.en_IE
dc.description.sponsorshipThis work was funded by grants from Science Foundation Ireland (10/IN.1/B2976) and a PhD Scholarship from the College of Science, National University of Ireland Galway.en_IE
dc.relation.ispartofPain in Psychiatric Disorders. Mod Trends Pharmacopsychiatryen
dc.subjectNegative affective stateen_IE
dc.subjectPeriaqueductal greyen_IE
dc.titleSupraspinal transient receptor potential subfamily V member 1 (TRPV1) in pain and psychiatric disordersen_IE
dc.typeBook chapteren_IE
dc.description.peer-reviewedPeer reviewed
dc.contributor.funderScience Foundation Irelanden_IE
dc.contributor.funderIrish Research Councilen_IE
dc.contributor.funderCollege of Science, National University of Ireland, Galwayen_IE
dc.local.contactDavid Finn, Dept. Of Pharmacology &, Therapeutics, Nui, Galway. 5280 Email:
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Principal Investigator Programme (PI)/10/IN.1/B2976/IE/The role of the endocannabinoid system in anxiety-induced modulation of pain: sites and mechanisms of action/en_IE

Files in this item

Attribution-NonCommercial-NoDerivs 3.0 Ireland
This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. Please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.

The following license files are associated with this item:


This item appears in the following Collection(s)

Show simple item record