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dc.contributor.authorMadasu, M.K.
dc.contributor.authorRoche, Michelle
dc.contributor.authorFinn, David P.
dc.date.accessioned2019-03-29T11:56:52Z
dc.date.available2019-03-29T11:56:52Z
dc.date.issued2015
dc.identifier.citationMadasu, M.K., Roche, Michelle, & Finn, David P. (2015). Supraspinal Transient Receptor Potential Subfamily V Member 1 (TRPV1) in Pain and Psychiatric Disorders. In David P. Finn & Brian E. Leonard (Eds.), Pain in Psychiatric Disorders: Modern Trends Pharmacopsychiatry (Vol. 30, pp. 80-93). Basel: Karger.en_IE
dc.identifier.issn1662-4505
dc.identifier.urihttp://hdl.handle.net/10379/15075
dc.description.abstractThe transient receptor potential subfamily V member 1 (TRPV1) belongs to the diverse transient receptor potential (TRP) family of cation channels. It was first characterized in primary afferent fibres as a receptor for capsaicin. Peripheral TRPV1 has a very well-described role in nociception. However, TRPV1 is now recognized to have a broader distribution and function, with supraspinal/brain TRPV1 known to modulate pain processing. Recently, studies employing histological, genetic and pharmacological approaches have provided evidence that supraspinal TRPV1 also modulates brain neurobiology and behaviours related to anxiety, depression and schizophrenia. Key brain regions involved in TRPV1-mediated modulation of pain and affect include the periaqueductal grey, hippocampus and medial prefrontal cortex. Thus, TRPV1 in the brain is emerging as an important molecular substrate which is dually implicated in both pain and psychiatric disorders, and represents a novel therapeutic target for these conditions and their comorbidity.en_IE
dc.description.sponsorshipThis work was funded by grants from Science Foundation Ireland (10/IN.1/B2976) and a PhD Scholarship from the College of Science, National University of Ireland Galway.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherKargeren_IE
dc.relation.ispartofPain in Psychiatric Disorders. Mod Trends Pharmacopsychiatryen
dc.subjectTRPV1en_IE
dc.subjectPainen_IE
dc.subjectNegative affective stateen_IE
dc.subjectPeriaqueductal greyen_IE
dc.subjectCapsaicinen_IE
dc.subjectRaten_IE
dc.titleSupraspinal transient receptor potential subfamily V member 1 (TRPV1) in pain and psychiatric disordersen_IE
dc.typeBook chapteren_IE
dc.date.updated2019-03-27T13:40:23Z
dc.identifier.doi10.1159/000435934
dc.local.publishedsourcehttps://doi.org/10.1159/000435934en_IE
dc.description.peer-reviewedPeer reviewed
dc.contributor.funderScience Foundation Irelanden_IE
dc.contributor.funderIrish Research Councilen_IE
dc.contributor.funderCollege of Science, National University of Ireland, Galwayen_IE
dc.internal.rssid10575297
dc.local.contactDavid Finn, Dept. Of Pharmacology &, Therapeutics, Nui, Galway. 5280 Email: david.finn@nuigalway.ie
dc.local.copyrightcheckedyes
dc.local.versionACCEPTED
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Principal Investigator Programme (PI)/10/IN.1/B2976/IE/The role of the endocannabinoid system in anxiety-induced modulation of pain: sites and mechanisms of action/en_IE
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