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dc.contributor.authorBree, Dara
dc.contributor.authorMoriarty, Orla
dc.contributor.authorBroom, Daniel C.
dc.contributor.authorKelly, John P.
dc.contributor.authorRoche, Michelle
dc.contributor.authorFinn, David P.
dc.date.accessioned2019-04-01T09:24:06Z
dc.date.available2019-04-01T09:24:06Z
dc.date.issued2015-12-10
dc.identifier.citationBree, Dara, Moriarty, Orla, Broom, Daniel C., Kelly, John P., Roche, Michelle, & Finn, David P. (2016). Characterization of the Affective Component of Acute Postoperative Pain Associated with a Novel Rat Model of Inguinal Hernia Repair Pain. CNS Neuroscience & Therapeutics, 22(2), 146-153. doi: 10.1111/cns.12483en_IE
dc.identifier.issn1755-5949
dc.identifier.urihttp://hdl.handle.net/10379/15082
dc.description.abstractAims: Acute postoperative pain remains a significant healthcare issue. Historically, the assessment of postoperative pain in rodents has relied on evoked withdrawal or reflexive measures. Using a recently developed, anatomically relevant rat model of acute postoperative pain (J Pain, 16, 2015, 421), the present experiments sought to investigate the affective component of acute postoperative pain associated with inguinal hernia repair. Methods: Male Lister hooded rats underwent surgery to model Lichtenstein inguinal hernia repair (without hernia induction), or a sham procedure. Postsurgical characterization involved a modified place escape/avoidance paradigm (mPEAP), as well as home cage and open field locomotor activity monitoring. In pharmacological validation studies, rats received either morphine or carprofen prior to mPEAP testing. Results: Surgery was associated with a significantly increased proportion of the trial duration in the light compartment of the mPEAP arena, in avoidance of the noxious stimulus, compared with sham animals. When retested in the mPEAP at day 7 postsurgery, there was no difference between sham and surgery animals for time spent in either compartment, but surgery animals displayed a persistent increase in the percentage response to noxious stimulation. Morphine and carprofen treatment in surgery animals reduced escape/avoidance behavior at discrete time points over the trial. Surgery-induced reductions in home cage and open field locomotor activity were also observed. Conclusion: The present studies report for the first time the characterization of the affective component of acute postoperative pain using the mPEAP in a rodent model, which may facilitate development of improved understanding and treatment of postoperative pain.en_IE
dc.description.sponsorshipThis project was funded by a grant from the Irish Industrial Development Agency in partnership with Covidien.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherWileyen_IE
dc.relation.ispartofCns Neuroscience & Therapeuticsen
dc.subjectAffecten_IE
dc.subjectCarprofenen_IE
dc.subjectHernia repairen_IE
dc.subjectLocomotor activityen_IE
dc.subjectMorphineen_IE
dc.subjectPEAPen_IE
dc.subjectPostsurgical painen_IE
dc.subjectPLACE ESCAPE/AVOIDANCE BEHAVIORen_IE
dc.subjectQUALITY-OF-LIFEen_IE
dc.subjectNEUROPATHIC PAINen_IE
dc.subjectMECHANICAL HYPERALGESIAen_IE
dc.subjectINFLAMMATORY PAINen_IE
dc.subjectACTIVATIONen_IE
dc.subjectANALGESIAen_IE
dc.subjectPARADIGMen_IE
dc.subjectSURGERYen_IE
dc.subjectINJURYen_IE
dc.titleCharacterization of the affective component of acute postoperative pain associated with a novel rat model of inguinal hernia repair painen_IE
dc.typeArticleen_IE
dc.date.updated2019-03-27T22:56:50Z
dc.identifier.doi10.1111/cns.12483
dc.local.publishedsourcehttps://doi.org/10.1111/cns.12483en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderIDA Irelanden_IE
dc.contributor.funderCovidienen_IE
dc.internal.rssid10563069
dc.local.contactDavid Finn, Dept. Of Pharmacology &, Therapeutics, Nui, Galway. 5280 Email: david.finn@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
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