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dc.contributor.authorMadasu, Manish K.
dc.contributor.authorRoche, Michelle
dc.contributor.authorFinn, David P.
dc.date.accessioned2019-04-02T14:51:56Z
dc.date.available2019-04-02T14:51:56Z
dc.date.issued2015
dc.identifier.citationMadasu, M. K., Roche, M., & Finn, D. P. (2015). Supraspinal Transient Receptor Potential Subfamily V Member 1 (TRPV1) in Pain and Psychiatric Disorders. In Finn, David P. & Leonard, Brian E. (Eds.), Pain in Psychiatric Disorders: Modern Trends Pharmacopsychiatry (Vol. 30, pp. 80-93). Basel: Karger. doi: 10.1159/000435934en_IE
dc.identifier.urihttp://hdl.handle.net/10379/15090
dc.description.abstractThe transient receptor potential subfamily V member 1 (TRPV1) belongs to the diverse transient receptor potential (TRP) family of cation channels. It was first characterized in primary afferent fibres as a receptor for capsaicin. Peripheral TRPV1 has a very well-described role in nociception. However, TRPV1 is now recognized to have a broader distribution and function, with supraspinal/brain TRPV1 known to modulate pain processing. Recently, studies employing histological, genetic and pharmacological approaches have provided evidence that supraspinal TRPV1 also modulates brain neurobiology and behaviours related to anxiety, depression and schizophrenia. Key brain regions involved in TRPV1-mediated modulation of pain and affect include the periaqueductal grey, hippocampus and medial prefrontal cortex. Thus, TRPV1 in the brain is emerging as an important molecular substrate which is dually implicated in both pain and psychiatric disorders, and represents a novel therapeutic target for these conditions and their comorbidity. (C) 2015 S. Karger AG, Baselen_IE
dc.description.sponsorshipThis work was funded by grants from Science Foundation Ireland (10/IN.1/B2976) and a PhD Scholarship from the College of Science, National University of Ireland Galway.en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherKargeren_IE
dc.relation.ispartofMetabolic Effects Of Psychotropic Drugsen
dc.subjectDORSOLATERAL PERIAQUEDUCTAL GRAYen_IE
dc.subjectVANILLOID TYPE-1 CHANNELSen_IE
dc.subjectMEDIAL PREFRONTAL CORTEXen_IE
dc.subjectACID AMIDE HYDROLASEen_IE
dc.subjectROSTRAL VENTROMEDIAL MEDULLAen_IE
dc.subjectN-ARACHIDONOYL-SEROTONINen_IE
dc.subjectADULT-RAT BRAINen_IE
dc.subjectENDOCANNABINOID SYSTEMen_IE
dc.subjectSCHIZOPHRENIC-PATIENTSen_IE
dc.subjectCAPSAICIN RECEPTORen_IE
dc.titleSupraspinal Transient Receptor Potential Subfamily V Member 1 (TRPV1) in pain and psychiatric disordersen_IE
dc.typeArticleen_IE
dc.date.updated2019-03-28T05:47:41Z
dc.identifier.doi10.1159/000435934
dc.local.publishedsourcehttps://doi.org/10.1159/000435934en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funderScience Foundation Irelanden_IE
dc.contributor.funderCollege of Science, National University of Ireland, Galwayen_IE
dc.internal.rssid11876651
dc.local.contactDavid Finn, Dept. Of Pharmacology &, Therapeutics, Nui, Galway. 5280 Email: david.finn@nuigalway.ie
dc.local.copyrightcheckedYes
dc.local.versionACCEPTED
dcterms.projectinfo:eu-repo/grantAgreement/SFI/SFI Principal Investigator Programme (PI)/10/IN.1/B2976/IE/The role of the endocannabinoid system in anxiety-induced modulation of pain: sites and mechanisms of action/en_IE
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