Show simple item record

dc.contributor.authorAied, Ahmed
dc.contributor.authorGlynn, Barry
dc.contributor.authorCao, Hongliang
dc.contributor.authorZheng, Yu
dc.contributor.authorPandit, Abhay
dc.contributor.authorWang, Wenxin
dc.identifier.citationAied, A,Glynn, B,Cao, HL,Zheng, Y,Tai, HY,Pandit, A,Wang, WX (2012) 'A Fluorescently Labeled, Hyperbranched Polymer Synthesized from DE-ATRP for the Detection of DNA Hybridization'. Polymer Chemistry, 3 :332-334.en_US
dc.descriptionJournal articleen_US
dc.description.abstractThe early detection of oligonucleotide biomarkers of disease, such as microRNAs, has been established as a fundamental factor in cancer diagnosis. As the levels of these small molecules (microRNAs) in blood have recently been found to be significantly affected in cancer patients, they offer a means of early stage detection of cancer. Towards the goal of creating a novel method of DNA hybridization detection, we report the detection of specific sequences of small oligonucleotides in a model experiment carried out in serum. The results shown here display the versatility of the DE-ATRP method in synthesizing a specific polymer structure capable of changing its physical properties in the presence of double stranded DNA. The polymer was labeled and used to detect single-stranded DNA in serum successfully.en_US
dc.publisherRoyal Society of Chemistryen_US
dc.relation.ispartofPolymer Chemistryen
dc.subjectConjugated polymersen_US
dc.subjectMicro RNAsen_US
dc.titleA Fluorescently Labeled, Hyperbranched Polymer Synthesized from DE-ATRP for the Detection of DNA Hybridizationen_US
dc.identifier.doiDOI 10.1039/c2py00516f
dc.local.contactAbhay Shashikant Pandit, Mechanical & Biomedical Eng, College Of Eng & Informatics, Room 304, Nfb Building, Ida Bus Park, Dangan, Nui Galway. 2758 Email:

Files in this item

Attribution-NonCommercial-NoDerivs 3.0 Ireland
This item is available under the Attribution-NonCommercial-NoDerivs 3.0 Ireland. No item may be reproduced for commercial purposes. Please refer to the publisher's URL where this is made available, or to notes contained in the item itself. Other terms may apply.

The following license files are associated with this item:


This item appears in the following Collection(s)

Show simple item record