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dc.contributor.authorRoche, Michelle
dc.contributor.authorFinn, David P.
dc.date.accessioned2013-07-15T14:28:55Z
dc.date.available2013-07-15T14:28:55Z
dc.date.issued2010
dc.identifier.citationRoche M, Finn DP (2010) 'Brain CB2 receptors: Implication for Neuropsychiatric disorders'. Pharmaceuticals (Invited Review), 3 (0):2517-2553.en_US
dc.identifier.urihttp://hdl.handle.net/10379/3510
dc.description.abstractAlthough previously thought of as the peripheral cannabinoid receptor, it is now accepted that the CB2 receptor is expressed in the central nervous system on microglia, astrocytes and subpopulations of neurons. Expression of the CB2 receptor in the brain is significantly lower than that of the CB1 receptor. Conflicting findings have been reported on the neurological effects of pharmacological agents targeting the CB2 receptor under normal conditions. Under inflammatory conditions, CB2 receptor expression in the brain is enhanced and CB2 receptor agonists exhibit potent anti-inflammatory effects. These findings have prompted research into the CB2 receptor as a possible target for the treatment of neuroinflammatory and neurodegenerative disorders. Neuroinflammatory alterations are also associated with neuropsychiatric disorders and polymorphisms in the CB2 gene have been reported in depression, eating disorders and schizophrenia. This review will examine the evidence to date for a role of brain CB2 receptors in neuropsychiatric disorders.en_US
dc.formatapplication/pdfen_US
dc.language.isoenen_US
dc.relation.ispartofPharmaceuticals (Invited Review)en
dc.subjectEndocannabinoiden_US
dc.subjectCB(2)en_US
dc.subjectDepressionen_US
dc.subjectStressen_US
dc.subjectSchizophreniaen_US
dc.subjectNeurophysiologyen_US
dc.titleBrain CB2 receptors: Implication for Neuropsychiatric disordersen_US
dc.typeArticleen_US
dc.date.updated2013-07-09T15:02:23Z
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.internal.rssid4603107
dc.local.contactMichelle Roche, Dept Of Physiology, Nui Galway. 5427 Email: michelle.roche@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
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