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dc.contributor.authorZhao, Feihu
dc.contributor.authorVaughan, Ted J.
dc.contributor.authorMcNamara, Laoise M.
dc.date.accessioned2016-12-13T09:49:56Z
dc.date.issued2016-06
dc.identifier.citationZhao, Feihu, Vaughan, Ted J., & McNamara, Laoise M. (2016). Quantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architectures. Biomechanics and Modeling in Mechanobiology, 15(3), 561-577. doi: 10.1007/s10237-015-0710-0en_IE
dc.identifier.issn1617-7940
dc.identifier.urihttp://hdl.handle.net/10379/6224
dc.description.abstractRecent studies have shown that mechanical stimulation, in the form of fluid perfusion and mechanical compression, can enhance osteogenic differentiation of mesenchymal stem cells and bone cells within tissue engineering scaffolds in vitro. The precise nature of mechanical stimulation within tissue engineering scaffolds is not only dictated by the exogenously applied loading regime, but also depends on the geometric features of the scaffold, in particular architecture, pore size and porosity. However, the precise contribution of each geometric feature towards the resulting mechanical stimulation within a scaffold is difficult to characterise due to the wide range of interacting parameters. In this study, we have applied a fluid-structure interaction model to investigate the role of scaffold geometry (architecture, pore size and porosity) on pore wall shear stress (WSS) under a range of different loading scenarios: fluid perfusion, mechanical compression and a combination of perfusion and compression. It is found that scaffold geometry (spherical and cubical pores), in particular the pore size, has a significant influence on the stimulation within scaffolds. Furthermore, we observed an amplified WSS within scaffolds under a combination of fluid perfusion and mechanical compression, which exceeded that caused by individual fluid perfusion or mechanical compression approximately threefold. By conducting this comprehensive parametric variation study, an expression was generated to allow the design and optimisation of 3D TE scaffolds and inform experimental loading regimes so that a desired level of mechanical stimulation, in terms of WSS is generated within the scaffold.en_IE
dc.description.sponsorshipThe authors would like to acknowledge the research grant from European Research Council (ERC) under grant number 258992 (BONEMECHBIO).en_IE
dc.formatapplication/pdfen_IE
dc.language.isoenen_IE
dc.publisherSpringer Verlagen_IE
dc.relation.ispartofBiomechanics And Modeling In Mechanobiologyen
dc.subjectBone tissue-engineered scaffolden_IE
dc.subjectScaffold geometryen_IE
dc.subjectMechanical stimulationen_IE
dc.subjectWall shear stressen_IE
dc.subjectComputational modellingen_IE
dc.subjectBiomedical engineeringen_IE
dc.subjectCollagen glycosaminoglycan scaffoldsen_IE
dc.subjectStem cell differentiationen_IE
dc.subjectMarrow stromal cellsen_IE
dc.subjectMechanical stimulationen_IE
dc.subjectOsteogenic differentiationen_IE
dc.subject3 dimensional scaffoldsen_IE
dc.subjectPerfusion bioreactoren_IE
dc.subjectSubstrate stiffnessen_IE
dc.subjectPorous scaffolden_IE
dc.subjectFlow perfusionen_IE
dc.titleQuantification of fluid shear stress in bone tissue engineering scaffolds with spherical and cubical pore architecturesen_IE
dc.typeArticleen_IE
dc.date.updated2016-12-07T14:57:10Z
dc.identifier.doi10.1007/s10237-015-0710-0
dc.local.publishedsourcehttp://dx.doi.org/10.1007/s10237-015-0710-0en_IE
dc.description.peer-reviewedpeer-reviewed
dc.contributor.funder|~|
dc.description.embargo2017-06-01
dc.internal.rssid11107022
dc.local.contactLaoise Mcnamara, Biomedical Engineering, Eng-3038, New Engineering Building, Nui Galway. 2251 Email: laoise.mcnamara@nuigalway.ie
dc.local.copyrightcheckedNo
dc.local.versionACCEPTED
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