Now showing items 1-8 of 8

    • Coordinated regulation of replication protein a activities by its subunits p14 and p32 

      Weisshart, Klaus; Pestryakov, Pavel; Smith, Richard W. P.; Hartmann, Hella; Kremmer, Elisabeth; Lavrik, Olga; Nasheuer, Heinz-Peter (American Society for Biochemistry & Molecular Biology (ASBMB), 2004-06-17)
      The heterotrimeric replication protein A (RPA) has multiple essential activities in eukaryotic DNA metabolism and in signaling pathways. Despite extensive analyses, the functions of the smallest RPA subunit p14 are still ...
    • Distinctive activities of dna polymerases during human dna replication 

      Rytkonen, Anna K.; Vaara, Markku; Nethanel, Tamar; Kaufmann, Gabriel; Sormunen, Raija; Laara, Esa; Nasheuer, Heinz-Peter; Rahmeh, Amal; Lee, Marietta Y. W. T.; Syvaoja, Juhani E.; Pospiech, Helmut (Wiley-Blackwell, 2006-07-01)
      The contributions of human DNA polymerases (pols) alpha, delta and epsilon during S-phase progression were studied in order to elaborate how these enzymes co-ordinate their functions during nuclear DNA replication. Pol ...
    • Dna polymerase ε associates with the elongating form of rna polymerase ii and nascent transcripts 

      Rytkönen, Anna K.; Hillukkala, Tomi; Vaara, Markku; Sokka, Miiko; Jokela, Maarit; Sormunen, Raija; Nasheuer, Heinz-Peter; Nethanel, Tamar; Kaufmann, Gabriel; Pospiech, Helmut; Syväoja, Juhani E. (Wiley-Blackwell, 2006-11-15)
      DNA polymerase epsilon co-operates with polymerases alpha and delta in the replicative DNA synthesis of eukaryotic cells. We describe here a specific physical interaction between DNA polymerase epsilon and RNA polymerase ...
    • Human replication protein a 

      Pestryakov, Pavel E.; Weisshart, Klaus; Schlott, Bernhard; Khodyreva, Svetlana N.; Kremmer, Elisabeth; Grosse, Frank; Lavrik, Olga I.; Nasheuer, Heinz-Peter (American Society for Biochemistry & Molecular Biology (ASBMB), 2003-02-24)
      Although the mechanical aspects of the single-stranded DNA (ssDNA) binding activity of human replication protein A (RPA) have been extensively studied, only limited information is available about its interaction with other ...
    • Initiation of jc virus dna replication in vitro by human and mouse dna polymerase alpha-primase 

      Smith, Richard W. P.; Nasheuer, Heinz-Peter (Wiley-Blackwell, 2003-05-01)
      Host species specificity of the polyomaviruses simian virus 40 (SV40) and mouse polyomavirus (PyV) has been shown to be determined by the host DNA polymerase alpha-primase complex involved in the initiation of both viral ...
    • Physical and functional modularity of the protein network in yeast 

      Wilhelm, Thomas; Nasheuer, Heinz-Peter; Huang, Sui (American Society for Biochemistry & Molecular Biology (ASBMB), 2003-05-01)
      While protein-protein interactions have been studied largely as a network graph without physicality, here we analyze two protein complex data sets of Saccharomyces cerevisiae to relate physical and functional modularity ...
    • Post-transcriptional expression regulation in the yeastsaccharomyces cerevisiaeon a genomic scale 

      Beyer, Andreas; Hollunder, Jens; Nasheuer, Heinz-Peter; Wilhelm, Thomas (American Society for Biochemistry & Molecular Biology (ASBMB), 2004-08-23)
      Based on large-scale data for the yeast Saccharomyces cerevisiae (protein and mRNA abundance, translational status, transcript length), we investigate the relation of transcription, translation, and protein turnover on a ...
    • Regulation of eukaryotic dna replication at the initiation step 

      Pollok, S.; Stoepel, J.; Bauerschmidt, C.; Kremmer, E.; Nasheuer, Heinz-Peter (Portland Press Ltd., 2003-02-01)
      The studies of cell growth and division have remained at the centre of biomedical research for more than 100 years. The combination of genetic, biochemical, molecular and cell biological techniques recently yielded a burst ...