Now showing items 1-7 of 7

    • Coordinated regulation of replication protein a activities by its subunits p14 and p32 

      Weisshart, Klaus; Pestryakov, Pavel; Smith, Richard W. P.; Hartmann, Hella; Kremmer, Elisabeth; Lavrik, Olga; Nasheuer, Heinz-Peter (American Society for Biochemistry & Molecular Biology (ASBMB), 2004-06-17)
      The heterotrimeric replication protein A (RPA) has multiple essential activities in eukaryotic DNA metabolism and in signaling pathways. Despite extensive analyses, the functions of the smallest RPA subunit p14 are still ...
    • Distinctive activities of dna polymerases during human dna replication 

      Rytkonen, Anna K.; Vaara, Markku; Nethanel, Tamar; Kaufmann, Gabriel; Sormunen, Raija; Laara, Esa; Nasheuer, Heinz-Peter; Rahmeh, Amal; Lee, Marietta Y. W. T.; Syvaoja, Juhani E.; Pospiech, Helmut (Wiley-Blackwell, 2006-07-01)
      The contributions of human DNA polymerases (pols) alpha, delta and epsilon during S-phase progression were studied in order to elaborate how these enzymes co-ordinate their functions during nuclear DNA replication. Pol ...
    • Dna polymerase ε associates with the elongating form of rna polymerase ii and nascent transcripts 

      Rytkönen, Anna K.; Hillukkala, Tomi; Vaara, Markku; Sokka, Miiko; Jokela, Maarit; Sormunen, Raija; Nasheuer, Heinz-Peter; Nethanel, Tamar; Kaufmann, Gabriel; Pospiech, Helmut; Syväoja, Juhani E. (Wiley-Blackwell, 2006-11-15)
      DNA polymerase epsilon co-operates with polymerases alpha and delta in the replicative DNA synthesis of eukaryotic cells. We describe here a specific physical interaction between DNA polymerase epsilon and RNA polymerase ...
    • Human replication protein a 

      Pestryakov, Pavel E.; Weisshart, Klaus; Schlott, Bernhard; Khodyreva, Svetlana N.; Kremmer, Elisabeth; Grosse, Frank; Lavrik, Olga I.; Nasheuer, Heinz-Peter (American Society for Biochemistry & Molecular Biology (ASBMB), 2003-02-24)
      Although the mechanical aspects of the single-stranded DNA (ssDNA) binding activity of human replication protein A (RPA) have been extensively studied, only limited information is available about its interaction with other ...
    • Initiation of jc virus dna replication in vitro by human and mouse dna polymerase alpha-primase 

      Smith, Richard W. P.; Nasheuer, Heinz-Peter (Wiley-Blackwell, 2003-05-01)
      Host species specificity of the polyomaviruses simian virus 40 (SV40) and mouse polyomavirus (PyV) has been shown to be determined by the host DNA polymerase alpha-primase complex involved in the initiation of both viral ...
    • Physical and functional modularity of the protein network in yeast 

      Wilhelm, Thomas; Nasheuer, Heinz-Peter; Huang, Sui (American Society for Biochemistry & Molecular Biology (ASBMB), 2003-05-01)
      While protein-protein interactions have been studied largely as a network graph without physicality, here we analyze two protein complex data sets of Saccharomyces cerevisiae to relate physical and functional modularity ...
    • Post-transcriptional expression regulation in the yeastsaccharomyces cerevisiaeon a genomic scale 

      Beyer, Andreas; Hollunder, Jens; Nasheuer, Heinz-Peter; Wilhelm, Thomas (American Society for Biochemistry & Molecular Biology (ASBMB), 2004-08-23)
      Based on large-scale data for the yeast Saccharomyces cerevisiae (protein and mRNA abundance, translational status, transcript length), we investigate the relation of transcription, translation, and protein turnover on a ...