Show simple item record

dc.contributor.authorCallagy, G. M.
dc.date.accessioned2018-08-24T08:24:18Z
dc.date.available2018-08-24T08:24:18Z
dc.date.issued2006-04-15
dc.identifier.citationCallagy, G. M. (2006). Bcl-2 is a prognostic marker in breast cancer independently of the nottingham prognostic index. Clinical Cancer Research 12 (8), 2468-2475
dc.identifier.issn1078-0432,1557-3265
dc.identifier.urihttp://hdl.handle.net/10379/8936
dc.description.abstractPurpose: Prognostication of breast cancer using clinicopathologic variables, although useful, remains imperfect. Many reports suggest that gene expression profiling can refine the current approach. Alternatively, it has been shown that panels of proteins assessed by immunohistochemistry might also be useful in this regard. We evaluate the prognostic potential of a panel of markers by immunohistochemistry in a large case series to establish if either a single marker or a panel could improve the prognostic power of the Nottingham Prognostic Index (NPI). We validated the results in an independent series. Experimental Design and Results: The expression of 13 biomarkers was evaluated in 930 breast cancers on a tissue microarray. Eight markers [estrogen receptor (ER), progesterone receptor (PR), Bcl-2, cyclin E, p53, MIB-1, cytokeratin 5/6, and HER2] showed a significant association with survival at 10 years on univariate analysis. On multivariate analysis that included these eight markers and the NPI, only the NPI [hazard ratio (HR), 1.35; 95% confidence interval (95% CI), 1.16-1.56; P=0.0005], ER (HR, 0.59; 95% CI, 0.39-0.88; P=0.011), and Bcl-2 (HR, 0,68; 95% CI, 0.46-0.99; P=0.055) were significant. In a subsequent multivariate analysis that included the NPI, ER, and Bcl-2, only Bcl-2 (HR, 0.62; 95% CI, 0.44-0.87; P=0.006) remained independent of NPI (HR, 1.50; 95% CI, 1.16-1.56; P=0.004). In addition, Bcl-2, used as a single marker, was more powerful than the use of a panel of markers. Based on these results, an independent series was used to validate the prognostic significance of Bcl-2. ER and PR were also evaluated in this validation series. Bcl-2 (HR, 0,83; 95% CI, 0.71-0.96; P=0.018) retained prognostic significance independent of the NPI (HR, 2.04; 95% CI, 1.67-2.51; P<0.001) with an effect that was maximal in the first 5 years. Conclusion: Bcl-2 is an independent predictor of breast cancer outcome and seems to be useful as a prognostic adjunct to the NPI, particularly in the first 5 years after diagnosis.
dc.publisherAmerican Association for Cancer Research (AACR)
dc.relation.ispartofClinical Cancer Research
dc.subjectterm-follow-up
dc.subjecttissue microarrays
dc.subjectmolecular classification
dc.subjectprotooncogene expression
dc.subjectin-vitro
dc.subjectcarcinomas
dc.subjectgrade
dc.subjectp53
dc.subjectchemotherapy
dc.subjectsurvival
dc.titleBcl-2 is a prognostic marker in breast cancer independently of the nottingham prognostic index
dc.typeArticle
dc.identifier.doi10.1158/1078-0432.ccr-05-2719
dc.local.publishedsourcehttp://clincancerres.aacrjournals.org/content/clincanres/12/8/2468.full.pdf
nui.item.downloads0


Files in this item

This item appears in the following Collection(s)

Show simple item record