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dc.contributor.authorEarly, E.M.
dc.contributor.authorHardy, H.
dc.contributor.authorForde, T.
dc.contributor.authorKane, M.
dc.date.accessioned2018-08-24T08:24:40Z
dc.date.available2018-08-24T08:24:40Z
dc.date.issued2001-05-18
dc.identifier.citationEarly, E.M. Hardy, H.; Forde, T.; Kane, M. (2001). Bactericidal effect of a whey protein concentrate with anti-helicobacter pylori activity. Journal of Applied Microbiology 90 (5), 741-748
dc.identifier.issn1364-5072,1365-2672
dc.identifier.urihttp://hdl.handle.net/10379/9092
dc.description.abstractAims: To investigate the effect of whey protein concentrate (WPC) enriched in anti-Helicobacter pylori antibodies on growth of the organism in vitro. Methods and Results: A WPC rich in H. pylori-specific antibodies was produced by immunizing lactating cows against H. pylori and processing pooled bulk milk samples into whey powder. The antibodies bound several proteins within the bacterial homogenate and were active at pH 5. In a complement-dependent reaction, the immune WPC was highly bactericidal against four H. pylori strains tested in vitro. Conclusions: WPC produced with milk from H. pylori-immunized cows contains antibodies that are active at the pH of the stomach, and bactericidal against H. pylori in vitro, via the classical complement pathway. Significance and Impact of the Study: This study has demonstrated the potential for use of WPC in the prevention/treatment of H. pylori infections.
dc.publisherWiley-Blackwell
dc.relation.ispartofJournal of Applied Microbiology
dc.subjectmilk immunoglobulin concentrate
dc.subjecthyperimmune bovine colostrum
dc.subjectescherichia-coli
dc.subjectoral challenge
dc.subjectcow colostrum
dc.subjectinfection
dc.subjectrotavirus
dc.subjectdiarrhea
dc.subjectgastroenteritis
dc.subjectinfants
dc.titleBactericidal effect of a whey protein concentrate with anti-helicobacter pylori activity
dc.typeArticle
dc.identifier.doi10.1046/j.1365-2672.2001.01301.x
dc.local.publishedsourcehttp://onlinelibrary.wiley.com/doi/10.1046/j.1365-2672.2001.01301.x/pdf
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