Show simple item record

dc.contributor.authorNachamkin, Irving
dc.contributor.authorUng, Huong
dc.contributor.authorMoran, Anthony P.
dc.contributor.authorYoo, Dale
dc.contributor.authorPrendergast, Martina M.
dc.contributor.authorNicholson, Mabel A.
dc.contributor.authorSheikh, Kazim
dc.contributor.authorHo, Tony
dc.contributor.authorAsbury, Arthur K.
dc.contributor.authorMcKhann, Guy M.
dc.contributor.authorGriffin, John W.
dc.date.accessioned2018-08-24T08:25:50Z
dc.date.available2018-08-24T08:25:50Z
dc.date.issued1999-05-01
dc.identifier.citationNachamkin, Irving; Ung, Huong; Moran, Anthony P. Yoo, Dale; Prendergast, Martina M.; Nicholson, Mabel A.; Sheikh, Kazim; Ho, Tony; Asbury, Arthur K.; McKhann, Guy M.; Griffin, John W. (1999). Ganglioside gm1 mimicry incampylobacterstrains from sporadic infections in the united states. The Journal of Infectious Diseases 179 (5), 1183-1189
dc.identifier.issn0022-1899,1537-6613
dc.identifier.urihttp://hdl.handle.net/10379/9618
dc.description.abstractTo determine whether GM1-like epitopes in Campylobacter species are specific to O serotypes associated with Guillain-Barre syndrome (GBS) or whether they are frequent among random Campylobacter isolates causing enteritis, 275 random enteritis-associated isolates of Campylobacter jejuni were analyzed. The isolates were collected in the United States using a cholera toxin-binding assay. Overall, 26.2% of the isolates were positive for the GM1-like epitope. Of the 36 different O serotypes in the sample, 21 (58.3%) contained no strains positive for GM1, whereas in 6 serotypes (16.7%), >50% of isolates were positive for GM1. GBS-associated serotypes were more likely to contain strains positive for GM1 than were non-GBS-associated serotypes (37.8% vs. 15.1%, P = .0116). The results suggest that humans are frequently exposed to strains exhibiting GM1-like mimicry and, while certain serotypes may be more likely to possess GM1-like epitopes, the presence of GM1-like epitopes on Campylobacter strains does not itself trigger GBS.
dc.publisherOxford University Press (OUP)
dc.relation.ispartofThe Journal of Infectious Diseases
dc.subjectguillain-barre-syndrome
dc.subjectmotor axonal neuropathy
dc.subjectmiller-fisher-syndrome
dc.subjectjejuni infection
dc.subjectmolecular mimicry
dc.subjecthelicobacter-pylori
dc.subjectchemical structures
dc.subjectnorthern china
dc.subjectcholera-toxin
dc.subjectcore region
dc.titleGanglioside gm1 mimicry incampylobacterstrains from sporadic infections in the united states
dc.typeArticle
dc.identifier.doi10.1086/314725
dc.local.publishedsourcehttps://academic.oup.com/jid/article-pdf/179/5/1183/17991894/179-5-1183.pdf
nui.item.downloads0


Files in this item

This item appears in the following Collection(s)

Show simple item record